GeneTex
United States (US)

TGF beta Receptor 2 antibody

Orthogonal
GTX129909_41836_20160428_WB_Fraction_18121410_893.jpg

Cat No. GTX129909

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
Not tested in other applications.

Calculated MW

65 kDa. ( Note )

Positive Control

Raji membrane extract

Predict Reactivity

Mouse, Rat, Rabbit, Bovine, Rhesus Monkey(>80% identity)
PROPERTIES

Form

Liquid

Buffer

1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.36mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human TGF beta Receptor 2. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

AAT3 antibody , FAA3 antibody , LDS1B antibody , LDS2B antibody , MFS2 antibody , RIIC antibody , TAAD2 antibody , TGF beta Receptor 2 antibody , TGF beta Receptor 2 antibody , TGFBR2 antibody , TGFR-2 antibody , TGFR2 antibody , TGFbeta RII antibody , transforming growth factor beta receptor II antibody

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES
GTX129909_41836_20160428_WB_Fraction_18121410_893.jpg

GTX129909 WB Image

Orthogonal

Raji whole cell and membrane extracts (30 µg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with TGF beta Receptor II antibody (GTX129909) diluted at 1:500.

REFERENCE
SDS
PBS.pdf
Glycerol.pdf
Proclin.pdf
Package List Price ($)
$ 319
$ 169