*Optimal dilutions/concentrations should be determined by the researcher.
|1:500 - 1:1000
Not tested in other applications.
0.42% Potassium phosphate, 0.87% Sodium chloride pH 7.3, 30% glycerol, 0.01% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.
KLH-conjugated synthetic peptide encompassing a sequence within the center region of TGF beta Receptor 2. The exact sequence is proprietary.
Purified by antigen-affinity chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Transforming Growth Factor Beta Receptor 2,Aat3,Faa3,Lds1B,Lds2,Lds2B,Mfs2,Riic,Taad2,Tbr-Ii,Tbrii,Tgfr-2,Tgfbeta-Rii,Tgfbr2
Cell membrane,Membrane raft
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
GTX32359 WB Image
WB analysis of A549 (A), NIH3T3L1 (B), KNRK (C), HepG2 (D) whole cell lysates using GTX32359 TGF beta Receptor 2 (phospho Ser225) antibody.