APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Dilution |
| 1-2 μg/ml |
| 0.5-1 μg/ml |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS carbohydrates
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
recombinant human TGF-β sRIII (betaglycan) expressed in NSO cells
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
transforming growth factor beta receptor 3 , BGCAN , betaglycan
Cellular Localization
Secreted,Cell membrane
Background
Most mammalian cells express three abundant high affinity receptors, which can bind and be cross-linked to TGF beta: the type I (53 kDa), type II (65 kDa), and type III (100-280 kDa) receptors, based upon the molecular mass of the cross-linked products analyzed by gel electrophoresis. Tbeta-RI and Tbeta-RII, the type I and II receptors, are type I transmembrane proteins with cytosolic domains containing a serine-threonine kinase. Both receptors are essential for signal transduction. The TGF beta type III receptor, or betaglycan, is a membrane-bound proteoglycan with a short cytoplasmic tail that has no apparent signaling motif. It binds TGF beta 2 (apparent Kd 100 pM) with slightly greater affinity than TGF beta 1 or TGF beta 3 (apparent Kda 300 pM). The main role of betaglycan seems to be in binding and then presenting TGF beta ligand to the signaling receptors Tbeta-RI and Tbeta-RII; overexpression of Tbeta-RIII in L6 myoblasts leads to a dramatic increase in TGF beta 2 binding to Tbeta-RI and Tbeta-RII.
Database
Research Area
REFERENCE
There are currently no references for TGF beta Receptor III antibody (GTX10854). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for TGF beta Receptor III antibody (GTX10854). Be the first to share your experience with this product.
