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TGF beta antibody [TB21]

Anti-TGF beta antibody [TB21] used in IHC (Paraffin sections) (IHC-P). GTX76527

Cat. No. GTX76527

Reference 14

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 TB21

Isotype

 IgG1

Application

 WB, IHC-P, IHC-Fr, FACS, ELISA

Reactivity

 Human, Mouse, Rat, Rabbit, Sheep, Bovine, Mink, Mustelid
Package
100 μg ($509)
See all TGF beta products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
ELISA Assay dependent
Not tested in other applications.

Product Note

Western blotting demonstrated that this antibody reacts with the dimeric (25 kDa) and monomeric (12.5 kDa) forms of TGF-beta under both non-reducing and reducing conditions, respectively.This antibody recognizes both human platelet-derived and recombinant TGF-beta1.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human Transforming Growth Factor Beta 1 from platelets.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_377394

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

LAP Antibody , CED Antibody , TGFB1 Antibody , transforming growth factor, beta 1 Antibody , TGFB Antibody , DPD1 Antibody , TGFbeta Antibody

Background

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]

Research Area

DATA IMAGES

Anti-TGF beta antibody [TB21] used in IHC (Paraffin sections) (IHC-P). GTX76527

GTX76527 IHC-P Image

IHC analysis of human brain tissue using GTX76527 TGF beta antibody [TB21].

REFERENCE

Clone Reference

Sampaio LP et al. Transl Vis Sci Technol 2022; 11 (7):9 Topical Losartan and Corticosteroid Additively Inhibit Corneal Stromal Myofibroblast Generation and Scarring Fibrosis After Alkali Burn Injury.
Naike Casagrande et al. Int J Mol Sci 2021; 22 (6)
de Oliveira RC et al. Exp Eye Res 2021; 202:108325 TGFβ1 and TGFβ2 proteins in corneas with and without stromal fibrosis: Delayed regeneration of apical epithelial growth factor barrier and the epithelial basement membrane in corneas with stromal fibrosis.
Zhou Y et al. Oncol Lett 2020; 20 (6):298 Anti-CD206 antibody-conjugated Fe3O4-based PLGA nanoparticles selectively promote tumor-associated macrophages to polarize to the pro-inflammatory subtype.
Li L et al. Breast Cancer Res 2020; 22 (1):84 Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance.
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REVIEW

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Application Reference
Carlin GL et al. Eur J Obstet Gynecol Reprod Biol X 2020; 7:100111 The role of transforming growth factor-? (TGF-?1) in postmenopausal women with pelvic organ prolapse: An immunohistochemical study.
Lee E et al. Cancer 2013; 119 (9):1752-60 Cohypermethylation of p14 in combination with CADM1 or DCC as a recurrence-related prognostic indicator in stage I esophageal squamous cell carcinoma.
Application : IHC-P
Reactivity : Human
Hakim SG et al. Radiother Oncol 2011; 101 (1):34213 Expression of Wnt-1, TGF-β and related cell-cell adhesion components following radiotherapy in salivary glands of patients with manifested radiogenic xerostomia.
Application : IHC-P
Reactivity : Human
Clone Reference
Sampaio LP et al. Transl Vis Sci Technol 2022; 11 (7):9 Topical Losartan and Corticosteroid Additively Inhibit Corneal Stromal Myofibroblast Generation and Scarring Fibrosis After Alkali Burn Injury.
Naike Casagrande et al. Int J Mol Sci 2021; 22 (6)
de Oliveira RC et al. Exp Eye Res 2021; 202:108325 TGFβ1 and TGFβ2 proteins in corneas with and without stromal fibrosis: Delayed regeneration of apical epithelial growth factor barrier and the epithelial basement membrane in corneas with stromal fibrosis.
Licini C et al. Eur J Histochem 2020; 64 (4) Heterotopic ossification in a patient with diffuse idiopathic skeletal hyperostosis: Input from histological findings.
Zhou Y et al. Oncol Lett 2020; 20 (6):298 Anti-CD206 antibody-conjugated Fe3O4-based PLGA nanoparticles selectively promote tumor-associated macrophages to polarize to the pro-inflammatory subtype.
Li L et al. Breast Cancer Res 2020; 22 (1):84 Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance.
Grabias BM et al. Am J Physiol Renal Physiol 2013; 305 (1):F123-33 Notch4-dependent antagonism of canonical TGF-β1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells.
Insalaco L et al. J Cell Mol Med 2012; 16 (9):2186-95 analysis of molecular mechanisms and anti-tumoural effects of * acid in breast cancer cells.
Jung Y et al. Int J Oncol 2012; 40 (4):1122-32 Identification of prognostic biomarkers for glioblastomas using protein expression profiling.
Cayli S et al. Acta Histochem 2012; 114 (1):43441 Jab1 expression is associated with TGF-β1 signaling in chronic rhinosinusitis and nasal polyposis.
Crawford SE et al. Cell 1998; 93 (7):1159-70 Thrombospondin-1 is a major activator of TGF-beta1 in vivo.
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 509