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TGN46 antibody

Anti-TGN46 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX74290
Anti-TGN46 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX74290

Cat. No. GTX74290

Reference 12

Host

 Sheep

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-Fr

Reactivity

 Human
Package
50 μl ($409)
See all TGN46 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1/500-1/1,000
ICC/IF Assay dependent
IHC-Fr 1/50-1/100

Note :

IHC-Fr
Fixation with 3% paraformaldehyde or methanol/acetone is recommended.
Not tested in other applications.

Calculated MW

51 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 25% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human TGN46.

Purification

Serum

Conjugation

Unconjugated

RRID

AB_1952846

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

trans-golgi network protein 2 , TGN38 , TGN46 , TGN48 , TGN51 , TTGN2

Cellular Localization

Cell membrane; Single-pass type I membrane protein

Background

This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Database

Research Area

DATA IMAGES

Anti-TGN46 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX74290

GTX74290 ICC/IF Image

The data was published in the journal Nat Commun in 2016.PMID: 26879543

Anti-TGN46 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX74290

GTX74290 ICC/IF Image

The data was published in the journal Cilia in 2017. PMID: 28344780

REFERENCE

Application Reference

Nathaniel H O Harder et al. Front Mol Biosci 2022; 9 : 863296 Fatty Acid Uptake in Liver Hepatocytes Induces Relocalization and Sequestration of Intracellular Copper.
Application : ICC/IF
Reactivity : Human
McCann CJ et al. Metallomics 2019; 11 (6) : 1128-1139 Single nucleotide polymorphisms in the human ATP7B gene modify the properties of the ATP7B protein.
Application : ICC/IF
Reactivity : Human
McGough IJ et al. Nat Commun 2018; 9 (1) : 3737 SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.
Application : ICC/IF
Reactivity : Human
Danson CM et al. J Cell Sci 2018; (Epub) Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin.
Application : ICC/IF
Reactivity : Human
Zhao Y et al. EMM 2017; 49 : e405 Intracellular trafficking of TREM2 is regulated by presenilin 1.
Application : ICC/IF
Reactivity : Human
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REVIEW

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Application Reference
Nathaniel H O Harder et al. Front Mol Biosci 2022; 9:863296 Fatty Acid Uptake in Liver Hepatocytes Induces Relocalization and Sequestration of Intracellular Copper.
Application : ICC/IF
Reactivity : Human
McCann CJ et al. Metallomics 2019; 11 (6):1128-1139 Single nucleotide polymorphisms in the human ATP7B gene modify the properties of the ATP7B protein.
Application : ICC/IF
Reactivity : Human
McGough IJ et al. Nat Commun 2018; 9 (1):3737 SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.
Application : ICC/IF
Reactivity : Human
Danson CM et al. J Cell Sci 2018; (Epub) Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin.
Application : ICC/IF
Reactivity : Human
Zhao Y et al. EMM 2017; 49:e405 Intracellular trafficking of TREM2 is regulated by presenilin 1.
Application : ICC/IF
Reactivity : Human
Kane MS et al. Cilia 2017; 6:2 Abnormal glycosylation in Joubert syndrome type 10.
Application : ICC/IF
Reactivity : Human
Hatori Y et al. Nat Commun 2016; 7:10640 Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway.
Application : ICC/IF
Reactivity : Human
Davids M et al. J Med Genet 2015; Disruption of Golgi morphology and altered protein glycosylation in PLA2G6-associated neurodegeneration.
Application : ICC/IF
Reactivity : Human
Malinouski M et al. Nat Commun 2014; 5:3301 Genome-wide RNAi ionomics screen reveals new genes and regulation of human trace element metabolism.
Application : ICC/IF
Reactivity : Human
Huster D et al. Gastroenterology 2012; 142 (4):947-956.e5 Diverse functional properties of Wilson disease ATP7B variants.
Application : ICC/IF
Reactivity : Human
Dmitriev OY et al. J Biol Chem 2011; 286 (18):16355-62 Difference in stability of the N-domain underlies distinct intracellular properties of the E1064A and H1069Q mutants of copper-transporting ATPase ATP7B.
Application : ICC/IF
Reactivity : Human
Ryo A et al. Proc Natl Acad Sci U S A 2008; 105 (1):294-9 SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag.
Application : ICC/IF
Reactivity : Human
SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409