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TIE1 antibody [12D9]

Anti-TIE1 antibody [12D9] used in IHC (Paraffin sections) (IHC-P). GTX52470

Cat. No. GTX52470

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 12D9

Isotype

 IgG1

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all TIE1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:1000
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

125 kDa. ( Note )

Product Note

This antibody recognizes human Tie1 in western blot without cross reactivity with human Tie2.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

hTie1 extracellular domain

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

JTK14 , TIE , TIE1 , tyrosine kinase with immunoglobulin like and EGF like domains 1

Cellular Localization

Cell membrane

Background

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Database

Research Area

DATA IMAGES

Anti-TIE1 antibody [12D9] used in IHC (Paraffin sections) (IHC-P). GTX52470

GTX52470 IHC-P Image

IHC-P analysis of formalin fixed human placenta tissue using GTX52470 TIE1 antibody [12D9].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399