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TIMP1 antibody [4A16]

Anti-TIMP1 antibody [4A16] used in IHC (Paraffin sections) (IHC-P). GTX52486

Cat. No. GTX52486

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4A16

Isotype

 IgG2

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all TIMP1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:100 - 1:1000
IHC-P 1:25 - 1:50
Not tested in other applications.

Calculated MW

23 kDa. ( Note )

Product Note

This antibody recognizes human TIMP-1 in western blot. No cross-reactivity to human TIMP-2 is noted.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human recombinant TIMP-1 protein

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CLGI , EPA , EPO , HCI , TIMP , TIMP metallopeptidase inhibitor 1 , TIMP1

Cellular Localization

Secreted

Background

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-TIMP1 antibody [4A16] used in IHC (Paraffin sections) (IHC-P). GTX52486

GTX52486 IHC-P Image

IHC-P analysis of formalin fixed human placenta tissue using GTX52486 TIMP1 antibody [4A16].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399