TIMP1 antibody [C2C3], C-term

Name: TIMP1 antibody [C2C3], C-term
Brand: GeneTex
SKU: GTX108254
Price: 399.00 USD
Rating: 5 (2 reviews)

Cat. No. GTX108254

Reference 6

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P
Reactivity	Human, Mouse
Package	100 μl ($399), 25 μl ($169)

See all TIMP1 products

View product citations for antibody GTX108254 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	Assay dependent
IHC-P	Assay dependent

Not tested in other applications.

Calculated MW

23 kDa. ( Note )

Predict Reactivity

Bovine(>80% identity)

PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human TIMP1. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1952251

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TIMP metallopeptidase inhibitor 1 , CLGI , EPA , EPO , HCI , TIMP , TIMP-1

Cellular Localization

Secreted

Background

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq]

Database

Gene ID: 7076 TIMP1
UniProt: P01033 TIMP1

Research Area

REFERENCE

Application Reference

Perp?tuo L et al. Int J Mol Sci 2022; 23 (21) Coronary Artery Disease and Aortic Valve Stenosis: A Urine Proteomics Study.

Chang HH et al. Aging (Albany NY) 2020; 12 (21) : 21253-21272 Regulation of the regenerative activity of dental pulp stem cells from exfoliated deciduous teeth (SHED) of children by TGF-β1 is associated with ALK5/Smad2, TAK1, p38 and MEK/ERK signaling.

Application : WB

Reactivity : Human

Chen S et al. J Cell Biochem 2020; (Epub) M₃ receptor modulates extracellular matrix synthesis via ERK1/2 signaling pathway in human bladder smooth muscle cells.

Application : WB

Reactivity : Human

Amador C. V. et al. J Clin Exp Pathol 2017; 7 : 6 MUC1 and C-Met Affects Proliferation, Intercellular Junctions and Invasion in Two Head and Neck Carcinoma Cell Lines.

Application : WB

Reactivity : Human

Laudanski P et al. Eur J Obstet Gynecol Reprod Biol 2014; 172 : 85-92 Profiling of selected angiogenesis-related genes in proliferative eutopic endometrium of women with endometriosis.

Application : WB

Reactivity : Human

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