GeneTex

  • Country / Location Selection

United States (US)

TIMP2 antibody

Orthogonal
Anti-TIMP2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX16392
Anti-TIMP2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX16392
Anti-TIMP2 antibody used in Western Blot (WB). GTX16392
Anti-TIMP2 antibody used in Western Blot (WB). GTX16392

Cat. No. GTX16392

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all TIMP2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
ICC/IF 1:50 - 1:200
Not tested in other applications.

Calculated MW

24 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TIMP2 (NP_003246.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_2887534

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TIMP metallopeptidase inhibitor 2 , CSC-21K , DDC8

Cellular Localization

Secreted

Background

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-TIMP2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX16392

GTX16392 ICC/IF Image

ICC/IF analysis of C6 cells using GTX16392 TIMP2 antibody.
Blue : DAPI
Dilution : 1:100

Anti-TIMP2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX16392

GTX16392 ICC/IF Image

ICC/IF analysis of U2OS cells using GTX16392 TIMP2 antibody.
Blue : DAPI
Dilution : 1:100

Anti-TIMP2 antibody used in Western Blot (WB). GTX16392

GTX16392 WB Image

WB analysis of various sample lysates using GTX16392 TIMP2 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-TIMP2 antibody used in Western Blot (WB). GTX16392

GTX16392 WB Image

Orthogonal

The data was published in the journal Sci Rep in 2019.PMID: 31471547

REFERENCE

Application Reference

Wong MK et al. Sci Rep 2019; 9 (1) : 12607 Transcriptomic and functional analyses of 3D placental extravillous trophoblast spheroids.
Application : WB
Reactivity : Human
Amador C. V. et al. J Clin Exp Pathol 2017; 7 : 6 MUC1 and C-Met Affects Proliferation, Intercellular Junctions and Invasion in Two Head and Neck Carcinoma Cell Lines.
Application : WB
Reactivity : Human
Submit a Reference

REVIEW

There are currently no reviews for TIMP2 antibody (GTX16392). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399