APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500 - 1:2000 |
| 1:50 - 1:200 |
| 1:50 - 1:200 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant funsion protein containing a sequence corresponding to amino acids 1-221 of human TIRAP (NP_001034750.1).
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
TIR domain containing adaptor protein , BACTS1 , Mal , MyD88-2 , wyatt
Cellular Localization
Cytoplasm,Cell membrane,Membrane
Background
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX65910 IHC-P Image
IHC-P analysis of mouse kidney tissue using GTX65910 TIRAP antibody.
Dilution : 1:100
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GTX65910 IHC-P Image
IHC-P analysis of mouse liver tissue using GTX65910 TIRAP antibody.
Dilution : 1:100
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GTX65910 ICC/IF Image
ICC/IF analysis of U2OS cells using GTX65910 TIRAP antibody.
Blue : DAPI
Dilution : 1:100
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GTX65910 IHC-P Image
IHC-P analysis of rat kidney tissue using GTX65910 TIRAP antibody.
Dilution : 1:100
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GTX65910 WB Image
WB analysis of various sample lysates using GTX65910 TIRAP antibody.
Dilution : 1:1000
Loading : 25μg per lane
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REFERENCE
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REVIEW
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