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TL1A antibody [VEGI/1283]

Anti-TL1A antibody [VEGI/1283] used in IHC (Paraffin sections) (IHC-P). GTX35124
Anti-TL1A antibody [VEGI/1283] used in IHC (Paraffin sections) (IHC-P). GTX35124

Cat No. GTX35124

Host Mouse
Clonality Monoclonal
Clone Name VEGI/1283
Isotype IgG1
Application WB, ICC/IF, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1-2ug/ml for 60 minutes at RT
ICC/IF 1-2ug/ml
IHC-P 1-2ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

28 kDa. ( Note )

Specificity/Sensitivity

VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human full-length VEGI fragment

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Tnf Superfamily Member 15,Tl1,Tl1A,Tnlg1B,Vegi,Vegi192A,Tnfsf15

Background

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Database

Research Area

DATA IMAGES
Anti-TL1A antibody [VEGI/1283] used in IHC (Paraffin sections) (IHC-P). GTX35124

GTX35124 IHC-P Image

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with VEGI Monoclonal Antibody (VEGI /1283).

Anti-TL1A antibody [VEGI/1283] used in IHC (Paraffin sections) (IHC-P). GTX35124

GTX35124 IHC-P Image

Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with VEGI Monoclonal Antibody (VEGI /1283).

Package List Price ($)
$ 329