GeneTex
United States (US)

TLR2 antibody [mT2.7] (Biotin)

Cat No. GTX16908

Host Mouse
Clonality Monoclonal
Clone Name mT2.7
Isotype IgG2a
Application ICC/IF, IHC-Fr, FACS, IP, ELISA, IHC-F
Reactivity Mouse
APPLICATION

Application Note

ELISA: Use at an assay dependent dilution. FACS: Use at an assay dependent dilution. ICC: Use at an assay dependent dilution. IHC-Fr: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. GTX16908 is also tested in binding studies (antagonizes murine and human TLR2). Is unsuitable for WB. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

89 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.2, no preservative added.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Synthetic peptide corresponding to Mouse TLR2. (unfortunately, the amino acid sequence is considered to be commercially sensitive)

Purification

Purified

Conjugation

Biotin

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Toll-Like Receptor 2,Ly105,Tlr2

Cellular Localization

Type I membrane protein

Background

This protein is a member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognise pathogen associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram positive bacteria and yeast via stimulation of NF kappaB.

Database

Research Area

REFERENCE