PBS with 0.02% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Synthetic peptide: RESQSYLVEDLERS, corresponding to amino acids 182-195 of Human ASC.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Pyd And Card Domain Containing,Asc,Card5,Tms,Tms-1,Tms1,Pycard
Cell Membrane. Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appeared as hollow, perinuclear spherical, ball-like structures.
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, aRC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1 (1-3). Ectopic expression of ASC/TMS1 induced Apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells (3,4). Overexpression of ASC/TMS1induced DNA fragmentation (4). ASC/TMS1 is expressed in a variety of human and mouse tissues (1, 2)