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TNF Receptor I antibody [H398] (Low Endotoxin)

Cat No. GTX00577-00

Host

Mouse

Clonality

Monoclonal

Clone Name

H398

Isotype

IgG2a

Application

IHC-P, IHC-Fr, FACS, IP, Functional Assay

Reactivity

Human
Package
100 μg ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
Functional Assay Assay dependent
Not tested in other applications.

Calculated MW

50 kDa. ( Note )

Specificity/Sensitivity

This antibody recognizes the extracellular domain of CD120a. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.2 μm filter sterilized.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full length human CD120a

Purification

Protein A purified

Endotoxin

Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CD120a,FPF,TBP1,TNF receptor superfamily member 1A,TNFAR,TNFR,TNFR1,TNFR55,TNFR60,TNFRI,TNFRSF1A,p55,p55R,p60,TNF receptor I,TNF-R1,TNF-RI

Cellular Localization

Cell membrane,Golgi apparatus membrane,Secreted

Background

This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]

Database

Research Area

REFERENCE

There are currently no references for TNF Receptor I antibody [H398] (Low Endotoxin) (GTX00577-00). Be the first to share your publications with this product.

REVIEW

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Package List Price ($)
$ 319