*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
This antibody recognizes the extracellular domain of CD120a. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.
PBS, 0.2 μm filter sterilized.
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
1 mg/ml (Please refer to the vial label for the specific concentration.)
Recombinant full length human CD120a
Protein A purified
Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
CD120a,FPF,TBP1,TNF receptor superfamily member 1A,TNFAR,TNFR,TNFR1,TNFR55,TNFR60,TNFRI,TNFRSF1A,p55,p55R,p60,TNF receptor I,TNF-R1,TNF-RI
Cell membrane,Golgi apparatus membrane,Secreted
This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]