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TNF Receptor I antibody [H398] (Low Endotoxin)

Cat. No. GTX00577-00

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 H398

Isotype

 IgG2a

Application

 IHC-P, IHC-Fr, FACS, IP, Functional Assay

Reactivity

 Human
Package
100 μg ($399)
See all TNF Receptor I products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
Functional Assay Assay dependent
Not tested in other applications.

Calculated MW

50 kDa. ( Note )

Product Note

This antibody recognizes the extracellular domain of CD120a. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full length human CD120a

Purification

Protein A purified

Endotoxin

< 0.01 EU/μg (determined by the LAL assay)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD120a , FPF , TBP1 , TNF receptor superfamily member 1A , TNFAR , TNFR , TNFR1 , TNFR55 , TNFR60 , TNFRI , TNFRSF1A , p55 , p55R , p60 , TNF receptor I , TNF-R1 , TNF-RI

Cellular Localization

Cell membrane,Golgi apparatus membrane,Secreted

Background

This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399
Custom Conjugations