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TNF Receptor I antibody [HM104] (PE)

Anti-TNF Receptor I antibody [HM104] (PE) used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX16198
Anti-TNF Receptor I antibody [HM104] (PE) used in Flow cytometry (FACS). GTX16198

Cat. No. GTX16198

Reference 1

Host

 Rat

Clonality

 Monoclonal

Clone Name

 HM104

Isotype

 IgG2a

Application

 ICC/IF, FACS

Reactivity

 Mouse
Package
500 μl ($429)
See all TNF Receptor I products

APPLICATION

Application Note

FACS: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

50 kDa. ( Note )

Product Note

Recognizes an extracellular region of mouse TNF Receptor I (also known as TNFR1, p55)

PROPERTIES

Form

Liquid

Buffer

PBS, BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

0.10 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Purification

Purified IgG

Conjugation

Phycoerythrin (PE)

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tumor necrosis factor receptor superfamily, member 1a , CD120a , FPF , TNF-R , TNF-R-I , TNF-R1 , TNF-R55 , TNF-alphaR1 , TNFAR , TNFR60 , TNFRI , TNFRp55 , TNFalpha-R1 , Tnfr-2 , Tnfr1 , p55 , p55-R

Cellular Localization

Cell membrane; Single-pass type I membrane protein , Golgi apparatus membrane

Background

This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mice lacking a functional copy of this gene exhibit impaired immune function. [provided by RefSeq, Sep 2016]

Database

Research Area

DATA IMAGES

Anti-TNF Receptor I antibody [HM104] (PE) used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX16198

GTX16198 ICC/IF Image

The data was published in the journal Front Immunol in 2019. PMID: 31921183

Anti-TNF Receptor I antibody [HM104] (PE) used in Flow cytometry (FACS). GTX16198

GTX16198 FACS Image

The data was published in the journal Front Immunol in 2019. PMID: 31921183

REFERENCE

Application Reference

Marahleh A et al. Front Immunol 2019; 10 : 2925 TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation.
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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 429