APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
1-2μg/ml |
15-25μg/ml |
0.5-1μg/ml |
Assay dependent |
Note :
ELISA
Using the concentrations stated the detection limit is 5 ng/well.
Neutralizing/Inhibition
This antibody neutralizes the biological effect of rhTNF RII, but not rhTNF RI.
|
Not tested in other applications.
Calculated MW
Product Note
Reacts with recombinant and native human soluble TNF-RII. This antibody neutralises the biological effect of rhTNF-RII, but not rhTNF-RI.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1.0 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
R-DNA.
Purification
Protein G purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
TNF receptor superfamily member 1B , CD120b , TBPII , TNF-R-II , TNF-R75 , TNFBR , TNFR1B , TNFR2 , TNFR80 , p75 , p75TNFR
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
Database
Research Area
REFERENCE
There are currently no references for TNF Receptor II antibody [2/220] (GTX42466). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for TNF Receptor II antibody [2/220] (GTX42466). Be the first to share your experience with this product.