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TNF Receptor II antibody [GT1237]

Recombinant antibody
Anti-TNF Receptor II antibody [GT1237] used in Western Blot (WB). GTX02834
Anti-TNF Receptor II antibody [GT1237] used in Western Blot (WB). GTX02834
Anti-TNF Receptor II antibody [GT1237] used in Western Blot (WB). GTX02834

Cat. No. GTX02834

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 GT1237

Isotype

 IgG

Application

 WB

Reactivity

 Human, Mouse, Rat
Package
100 μl ($419)
See all TNF Receptor II products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
Not tested in other applications.

Calculated MW

48 kDa. ( Note )

Observed MW

~70 kDa. The observed M.W. is based on the following publication. PMID: 12370298

PROPERTIES

Form

Liquid

Buffer

PBS, 0.05% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, we recommend adding 50% glycerol, then aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.48 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthesized peptide derived from human TNF Receptor II

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TNF receptor superfamily member 1B , CD120b , TBPII , TNF-R-II , TNF-R75 , TNFBR , TNFR1B , TNFR2 , TNFR80 , p75 , p75TNFR

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-TNF Receptor II antibody [GT1237] used in Western Blot (WB). GTX02834

GTX02834 WB Image

Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with TNF Receptor II antibody [GT1237] (GTX02834) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
The observed M.W. is based on the publication: PMID: 12370298

Anti-TNF Receptor II antibody [GT1237] used in Western Blot (WB). GTX02834

GTX02834 WB Image

WB analysis of various samples using GTX02834 TNF Receptor II antibody [GT1237].
Dilution : 1:1000
Loading : 25μg

Anti-TNF Receptor II antibody [GT1237] used in Western Blot (WB). GTX02834

GTX02834 WB Image

WB analysis of various samples using GTX02834 TNF Receptor II antibody [GT1237].
Dilution : 1:1000
Loading : 25μg

REFERENCE

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REVIEW

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Package List Price ($)
$ 419