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TNF Receptor II antibody [MR2-1]

Anti-TNF Receptor II antibody [MR2-1] used in Flow cytometry (FACS). GTX54417
Anti-TNF Receptor II antibody [MR2-1] used in ELISA (ELISA). GTX54417

Cat. No. GTX54417

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MR2-1

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-Fr, FACS, IP, ELISA, Functional Assay

Reactivity

 Human, Cynomolgus monkey, Rhesus Monkey
Package
50 μg ($399)
See all TNF Receptor II products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
ELISA Assay dependent
Functional Assay Assay dependent
Not tested in other applications.

Calculated MW

48 kDa. ( Note )

Product Note

The antibody MR2-1 reacts with the extra-cellular part of the TNF-RII. It also reacts with the soluble receptor.

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS, 0.1% BSA

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

100 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Purification

Purified IgG1

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD120b,TBPII,TNF receptor superfamily member 1B,TNFBR,TNFR1B,TNFR2,TNFR75,TNFR80,TNFRII,TNFRSF1B,p75,p75TNFR,TNF receptor II

Cellular Localization

Cell membrane,Secreted

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-TNF Receptor II antibody [MR2-1] used in Flow cytometry (FACS). GTX54417

GTX54417 FACS Image

FACS analysis of THP-1 cells using GTX54417 TNF Receptor II antibody [MR2-1].
Black : Cells only
Red : Isotype control
Blue : Primary antibody
Antibody amount : 1 μg/2.5x10⁵ cells

Anti-TNF Receptor II antibody [MR2-1] used in ELISA (ELISA). GTX54417

GTX54417 ELISA Image

ELISA analysis of recombinant human Soluble TNF Receptor II protein using GTX54417 TNF Receptor II antibody [MR2-1]. as capture antibody used in different concentrations.

REFERENCE

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REVIEW

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Package List Price ($)
$ 399