TNF alpha antibody [2C8]

Cat No. GTX28348

Host	Mouse
Clonality	Monoclonal
Clone Name	2C8
Isotype	IgG1
Application	IHC-P, IHC-Fr, ELISA
Reactivity	Human

See all TNF alpha products

Datasheet

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
IHC-P	Assay dependent
IHC-Fr	Assay dependent
ELISA	Assay dependent

Not tested in other applications.

Calculated MW

25.64 kDa. ( Note )

Specificity/Sensitivity

This antibody is effective in inhibition of the biological activity of recombinant and natural TNF-α.

PROPERTIES

Form

Liquid

Buffer

PBS pH 7.4, 0.09 % sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4º C.

Concentration

Batch dependent(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human recombinant tumor necrosis factor of alpha type.

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Tumor Necrosis Factor,Dif,Tnf-Alpha,Tnfa,Tnfsf2,Tnlg1F,Tnf

Cellular Localization

Cell membrane,Membrane,Secreted

Background

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]