TORC2 antibody [5B10]

Cat. No. GTX82754

Host	Mouse
Clonality	Monoclonal
Clone Name	5B10
Isotype	IgG1
Application	WB, ICC/IF, IHC-P, FACS, ELISA
Reactivity	Human, Monkey
Package	100 μl ($399)

See all TORC2 products

Datasheet
Document

View product citations for antibody GTX82754 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1/500 - 1/2000
ICC/IF	1/200 - 1/1000
IHC-P	1/200 - 1/1000
FACS	1/200 - 1/400
ELISA	1/10000

Not tested in other applications.

Calculated MW

73 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Ascites

Preservative

0.03% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Purified recombinant fragment of human CRTC2 expressed in E. Coli.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CREB regulated transcription coactivator 2 , TORC-2 , TORC2

Cellular Localization

Cytoplasm,Nucleus

Background

This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]

Database

Gene ID: 200186 CRTC2
UniProt: Q53ET0 CRTC2

Research Area

DATA IMAGES

GTX82754 IHC-P Image

IHC-P analysis of ovary tumour tissue (left) and lung cancer (right) using GTX82754 TORC2 antibody [5B10].

GTX82754 WB Image

WB analysis of HeLa (1) and HEK293 (2) cell lysate using GTX82754 TORC2 antibody [5B10].

GTX82754 FACS Image

FACS analysis of HeLa cells using GTX82754 TORC2 antibody [5B10].
Green : TORC2
Purple : negative control

GTX82754 ICC/IF Image

ICC/IF analysis of HeLa cells using GTX82754 TORC2 antibody [5B10].
Green : TORC2
Blue: DRAQ5 fluorescent DNA dye
Red: Actin filaments

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf

Package

List Price ($)

100 μl

$ 399

Qty