GeneTex
United States (US)

TPMT antibody

GTX16383_20180530_ICCIF_18121410_436.jpg
GTX16383_20180530_WB_18121410_482.jpg

Cat No. GTX16383

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
ICC/IF Assay dependent
Not tested in other applications.

Calculated MW

28 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human TPMT (NP_000358.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Thiopurine S-Methyltransferase,Tpmtd,Tpmt

Background

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq, Jul 2008]

Database

DATA IMAGES
GTX16383_20180530_ICCIF_18121410_436.jpg

GTX16383 ICC/IF Image

ICC/IF analysis of U2OS cell using GTX16383 TPMT antibody.
Blue : DAPI

GTX16383_20180530_WB_18121410_482.jpg

GTX16383 WB Image

WB analysis of K562 cell lysate using GTX16383 TPMT antibody.
Dilution : 1:1000
Loading : 25μg per lane

Package List Price ($)
$ 319