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TPO antibody [AC25]

Anti-TPO antibody [AC25] used in IHC (Paraffin sections) (IHC-P). GTX01955

Cat. No. GTX01955

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 AC25

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($679)
See all TPO products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:80

Note :

IHC-P
Heat induced epitope retrieval with Tris/ EDTA-based buffer, pH 9.0. Polymer detection recommended.
Not tested in other applications.

Calculated MW

103 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Antigen Species

Human

Immunogen

Prokaryotic recombinant protein containing 105 amino acids corresponding to a portion of the N-terminus of the human thyroid peroxidase molecule.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

thyroid peroxidase , MSA , TDH2A , TPX

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

Database

Research Area

DATA IMAGES

Anti-TPO antibody [AC25] used in IHC (Paraffin sections) (IHC-P). GTX01955

GTX01955 IHC-P Image

IHC-P analysis of thyroid, Graves' disease tissue using GTX01955 TPO antibody [AC25]. Note intense cytoplasmic staining of thyroid epithelial cells.

REFERENCE

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REVIEW

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Package List Price ($)
$ 679