GeneTex
United States (US)

TPO antibody [MoAb47]

Cat No. GTX12500

Host Mouse
Clonality Monoclonal
Clone Name MoAb47
Isotype IgG1
Application IHC-P
Reactivity Human
APPLICATION

Application Note

IHC-P: Use at a dilution of 1/10 - 1/25 in an ABC method. Perform heat mediated antigen retrieval with 1mM EDTA buffer, pH 9.0 before commencing with IHC staining protocol. We suggest an incubation period of 30-60 minutes at room temperature. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

103 kDa. ( Note )

Positive Control

Thyroid
PROPERTIES

Form

Liquid

Buffer

Preservative: Sodium Azide; Constituents: Tissue Culture Supernatant

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Human Thyroid Peroxidase purified from thyroid microsomes by immunoaffinity chromatography

Purification

Tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Thyroid Peroxidase,Msa,Tdh2A,Tpx,Tpo

Cellular Localization

Cytoplasmic

Background

Thyroid Peroxidase is a transmembrane protein of 107 kDa containing a heme prosthetic group and it is present on the apical surface of the thyroid follicular cells. It is the primary enzyme involved in thyroid hormone synthesis. Malignant thyroid tumors exhibit an anomaly in Thyroid Peroxidase resulting in lower antibody affinity. This antibody may be useful aid in the differentiation between the benign and malignant thyroid tumors.

Database

Research Area

Package List Price ($)
$ 329