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TRAIL antibody [55B709.3]

Anti-TRAIL antibody [55B709.3] used in Western Blot (WB). GTX12124
Anti-TRAIL antibody [55B709.3] used in IHC (Paraffin sections) (IHC-P). GTX12124

Cat. No. GTX12124

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 55B709.3

Isotype

 IgG1

Application

 WB, IHC-P

Reactivity

 Human, Cat, Dog
Package
50 μg ($399)
See all TRAIL products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/ml
IHC-P 5 μg/ml
Not tested in other applications.

Calculated MW

33 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

This monoclonal antibody was raised against a peptide corresponding to amino acids 17-35 of human TRAIL. This peptide sequence has been shown to be involved in TRAIL and DR5 (TRAIL-R2) interaction.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TNF superfamily member 10 , APO2L , Apo-2L , CD253 , TL2 , TNLG6A , TRAIL

Cellular Localization

Cell membrane,Secreted

Background

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-TRAIL antibody [55B709.3] used in Western Blot (WB). GTX12124

GTX12124 WB Image

WB analysis of Jurkat cell lysate using GTX12124 TRAIL antibody [55B709.3].

Anti-TRAIL antibody [55B709.3] used in IHC (Paraffin sections) (IHC-P). GTX12124

GTX12124 IHC-P Image

IHC-P analysis of human kidney tissue using GTX12124 TRAIL antibody [55B709.3].
Dilution : 5 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399