APPLICATION
Application Note
Blocking peptide for rabbit polyconal antibody to TRAIL(GTX22435).
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, BSA
Preservative
0.1% Sodium azide
Storage
Store this product at 4ºC, DO NOT FREEZE. The product is stable for one year from the date of shipment.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Region/Sequence
Peptide mapping to the carboxy terminus of human TRAIL.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
TNF superfamily member 10 , APO2L , Apo-2L , CD253 , TL2 , TNLG6A , TRAIL
Cellular Localization
Cell membrane , Secreted
Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Database
Research Area
REFERENCE
There are currently no references for TRAIL peptide (GTX22436). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for TRAIL peptide (GTX22436). Be the first to share your experience with this product.