GeneTex

  • Country / Location Selection

United States (US)

TREM-2b antibody [5J46]

KO/KD
Anti-TREM-2b antibody [5J46] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX53229
Anti-TREM-2b antibody [5J46] used in Western Blot (WB). GTX53229

Cat. No. GTX53229

Host

 Rat

Clonality

 Monoclonal

Clone Name

 5J46

Isotype

 IgG2

Application

 WB, ICC/IF, FACS, IHC

Reactivity

 Mouse
Package
100 μg ($399)
See all TREM-2b products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:1000
ICC/IF 1:50 - 1:100
FACS Assay dependent
IHC 1:50 - 1:100
Not tested in other applications.

Calculated MW

25 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Mouse recombinant protein of the extracellular domain of TREM-2b

Purification

Protein A/G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Cellular Localization

Cell membrane,Secreted

Background

The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Database

Research Area

DATA IMAGES

Anti-TREM-2b antibody [5J46] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX53229

GTX53229 ICC/IF Image

ICC/IF analysis of mouse microglia cells using GTX53229 TREM-2b antibody [5J46].

Anti-TREM-2b antibody [5J46] used in Western Blot (WB). GTX53229

GTX53229 WB Image

KO/KD

WB analysis of mouse microglia cells with or without TERM2 siRNA treatment using GTX53229 TREM-2b antibody [5J46].

REFERENCE

There are currently no references for TREM-2b antibody [5J46] (GTX53229). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for TREM-2b antibody [5J46] (GTX53229). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Package List Price ($)
$ 399