GeneTex
United States (US)

TRF1 antibody [3H11]

Cat No. GTX80331

Host Mouse
Clonality Monoclonal
Clone Name 3H11
Isotype IgG1
Application WB, ICC/IF, ELISA
Reactivity Human
APPLICATION

Application Note

Recommended Starting Dilutions:
For WB: Use at 1:100-1:200
For ICC/IF: Use at 1:100-1:200. Use Hela cells as positive control
Optimal dilutions should be determined experimentally by the researcher.

Calculated MW

50 kDa. ( Note )

Specificity/Sensitivity

Human TRF1
PROPERTIES

Form

Liquid

Buffer

PBS + 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Human TRF1

Purification

Protein A

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

hTRF1 AS, NIMA interacting protein 2, PIN2, t TRF1, TERF 1, TRBF 1, TRF 1, TTAGGG repeat binding factor 1, Telomeric protein Pin2/TRF1, Telomeric repeat binding factor (NIMA interacting) 1,

Cellular Localization

Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the mitotic spindle.

Background

The TRF1 gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. It is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.

Database

Research Area

Package List Price ($)
$ 419