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TRF1 antibody [8A5]

Anti-TRF1 antibody [8A5] used in Western Blot (WB). GTX70290

Cat No. GTX70290

Host

Mouse

Clonality

Monoclonal

Clone Name

8A5

Isotype

IgG1

Application

WB

Reactivity

Human
Package
100 μl ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
Not tested in other applications.

Calculated MW

50 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, pH 7.4. No preservatives.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Telomeric Repeat Binding Factor 1 , Pin2 , Trbf1 , Trf , Trf1 , Htrf1-As , T-Trf1 , Terf1

Background

TRF1 binds the double-stranded telomeric repeat sequence, TTAGGG. TRF1 and TRF2 are key components of vertebrate telomeres and bind to double-stranded telomeric DNA as homodimers. Dimerization involves the TRF homology (TRFH) domain, which also mediates interactions with other telomeric proteins. Despite a modest sequence identity, the 2 TRFH domains have the same entirely alpha-helical architecture, resembling a twisted horseshoe. The dimerization interfaces feature unique interactions that prevent heterodimerization. Mutational analysis of TRF1 corroborated the structural data and underscored the importance of the TRFH domain in dimerization, DNA binding, and telomere localization.

Database

Research Area

DATA IMAGES

Anti-TRF1 antibody [8A5] used in Western Blot (WB). GTX70290

GTX70290 WB Image

Sample (30 ug of whole cell lysate)
A: 293T
B: Raji
10% SDS PAGE
GTX70290 diluted at 1:1000

REFERENCE

There are currently no references for TRF1 antibody [8A5] (GTX70290). Be the first to share your publications with this product.

REVIEW

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SDS
PBS.pdf