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TRF2 antibody

Anti-TRF2 antibody used in IHC (Paraffin sections) (IHC-P). GTX13589
Anti-TRF2 antibody used in Immunoprecipitation (IP). GTX13589

Cat. No. GTX13589

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IP, ChIP assay

Reactivity

 Human, Mouse
Package
100 μg ($399)
See all TRF2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 2 μg/ml
ICC/IF 1:20 - 1:1000
IHC-P 15 μg/ml
IP 2 μg/ 10⁶ cells
ChIP assay 1:20 - 1:1000
Not tested in other applications.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Baculovirus expressed His-tagged whole length TRF2 protein was used for immunizing goat (NP_005643).

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Background

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.

Research Area

DATA IMAGES

Anti-TRF2 antibody used in IHC (Paraffin sections) (IHC-P). GTX13589

GTX13589 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX13589 TRF2 antibody.
Dilution : 15 μg/ml

Anti-TRF2 antibody used in Immunoprecipitation (IP). GTX13589

GTX13589 IP Image

IP analysis of HL-60 cell lysate using GTX13589 TRF2 antibody.
Lane 1 : IP with mouse anti-TRF2 antibody
Lane 2 : IP with control mouse IgG
Lane 3 : IP with goat anti-TRF2 antibody (GTX13589)
Lane 4 : IP with pre-immune goat IgG

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399