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TRIM5 (alpha isoform) antibody, Internal

Anti-TRIM5 (alpha isoform) antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX89426

Cat. No. GTX89426

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
100 μg ($419)
See all TRIM5 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 3-6μg/ml

Note :

IHC-P
Human Kidney shows cytoplasm staining in PCT.
Not tested in other applications.

Positive Control

The peptide used to generate this antibody is available for purchase (GTX89426-PEP).

Product Note

This antibody is expected to recognise isoform alpha (NP_149023.1) only.

PROPERTIES

Form

Liquid

Buffer

TBS, 0.5% BSA

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide with sequence CNIEKNENYQPK, from the internal region of the protein sequence according to NP_149023.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tripartite motif containing 5 , RNF88 , TRIM5alpha

Cellular Localization

Cytoplasm , Nucleus

Background

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

Database

Research Area

DATA IMAGES

Anti-TRIM5 (alpha isoform) antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX89426

GTX89426 IHC-P Image

IHC-P analysis of human kidney using GTX89426 TRIM5 (alpha isoform) antibody, Internal.
Antigen retrieval : citrate buffer pH 6
Dilution : 4μg/ml

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 419