GeneTex
United States (US)

TRP1 antibody [TYRP1/1564R]

GTX35151_20170712_IHC-P_18121410_633.jpg

Cat No. GTX35151

Host Rabbit
Clonality Monoclonal
Clone Name TYRP1/1564R
Isotype IgG
Application ICC/IF, IHC-P
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF 1-2ug/ml
IHC-P 5-10ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

61 kDa. ( Note )

Specificity/Sensitivity

It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human full-length TYRP1 protein

Purification

Ab purified by Protein A

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Tyrosinase Related Protein 1,Cas2,Catb,Gp75,Oca3,Trp,Trp1,Tyrp,B-Protein,Tyrp1

Background

This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]

Database

Research Area

DATA IMAGES
GTX35151_20170712_IHC-P_18121410_633.jpg

GTX35151 IHC-P Image

Formalin-fixed, paraffin-embedded human Melanoma stained with TYRP1 Recombinant Rabbit Monoclonal Antibody (TYRP1/1564R) using AEC Chromogen (red).

Package List Price ($)
$ 379