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TSG101 antibody [4A10]

Recombinant antibody KO/KD Orthogonal Overexpression
Anti-TSG101 antibody [4A10] used in IHC (Paraffin sections) (IHC-P). GTX70255
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Anti-TSG101 antibody [4A10] used in IHC (Paraffin sections) (IHC-P). GTX70255
Anti-TSG101 antibody [4A10] used in ELISA (ELISA). GTX70255
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Anti-TSG101 antibody [4A10] used in IHC (Paraffin sections) (IHC-P). GTX70255
Anti-TSG101 antibody [4A10] used in Flow cytometry (FACS). GTX70255
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255

Cat. No. GTX70255

Reference 196
27

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4A10

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, FACS, IP, ELISA, EM, IHC, IHC (Free Floating)

Reactivity

 Human, Mouse, Rat, Zebrafish, Dog, Hamster, Pig, Monkey
Package
100 μl ($399)
See all TSG101 products
PRODUCT

Summary

TSG101 antibody [4A10] is a well-validated and highly cited mouse monoclonal antibody that detects TSG101, a protein of 390 amino acids and a predicted molecular weight of 44 kDa that is a core constituent of the ESCRT-I complex. Reports have described it having both tumor suppressor and tumor enhancer activities. TSG101 is involved in exosome secretion and is commonly used as an exosome marker.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
ICC/IF 1:500-1:1000
IHC-P 1:100-1:1000
FACS 1:25-1:200
IP Assay dependent
ELISA Assay dependent
EM Assay dependent
IHC 1:100
IHC (Free Floating) Assay dependent
Not tested in other applications.

Calculated MW

44 kDa. ( Note )

Positive Control

293T , K562 , THP-1 , HL-60 , Neuro 2A , C8D30 , NIH-3T3 , Raw264.7 , C2C12 , NIH-3T3 , JC , BCL-1

Product Note

Knockdown/Knockout validation was supported by references (PMID:27226592)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No Preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.8 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Amino acids 167-374 of TSG101 protein expressed in E. coli.

Purification

Purified by antigen-affinity chromatography.
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_373239

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tumor susceptibility 101 , TSG10 , VPS23

Cellular Localization

Cytoplasm , Nucleus

Background

The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-TSG101 antibody [4A10] used in IHC (Paraffin sections) (IHC-P). GTX70255

GTX70255 IHC-P Image

TSG101 antibody [4A10] detects TSG101 protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded human lung cancer.
TSG101 stained by TSG101 antibody [4A10] (GTX70255) diluted at 1:50.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255

GTX70255 WB Image

KO/KD

Non-transfected (–) and transfected (+) 293T whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with TSG101 antibody [4A10] (GTX70255) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-TSG101 antibody [4A10] used in IHC (Paraffin sections) (IHC-P). GTX70255

GTX70255 IHC-P Image

TSG101 antibody [4A10] detects TSG101 protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded human ovarian cancer.
TSG101 stained by TSG101 antibody [4A10] (GTX70255) diluted at 1:100.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-TSG101 antibody [4A10] used in ELISA (ELISA). GTX70255

GTX70255 ELISA Image

ELISA detection of TSG101 using GTX118736 for capture at a concentration of 5 μg/mL and GTX70255 for detection at a concentration of 1.5 μg/mL.

Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255

GTX70255 WB Image

Various tissue extracts (50 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with TSG101 antibody [4A10] (GTX70255) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-TSG101 antibody [4A10] used in IHC (Paraffin sections) (IHC-P). GTX70255

GTX70255 IHC-P Image

TSG101 antibody [4A10] detects TSG101 protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded human breast carcinoma.
TSG101 stained by TSG101 antibody [4A10] (GTX70255) diluted at 1:100.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-TSG101 antibody [4A10] used in Flow cytometry (FACS). GTX70255

GTX70255 FACS Image

TSG101 antibody [4A10] (GTX70255) detects TSG101 protein by flow cytometry analysis.
Sample: THP-1 cell.
Black: Unlabelled sample was used as a control.
Red: TSG101 antibody [4A10] (GTX70255) dilution: 1:25.
Acquisition of 20,000 events were collected using a Dylight 488-conjugated secondary antibody for FACS analysis.

Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255

GTX70255 WB Image

Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with TSG101 antibody [4A10] (GTX70255) diluted at 1:500. The HRP-conjugated anti-mouset IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255

GTX70255 WB Image

TSG101 antibody [4A10] detects TSG101 protein by western blot analysis.
A. 30 μg NIH-3T3 whole cell lysate/extract
B. 30 μg JC whole cell lysate/extract
C. 30 μg BCL-1 whole cell lysate/extract
10% SDS-PAGE
TSG101 antibody [4A10] (GTX70255) dilution: 1:500
The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255

GTX70255 WB Image

Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with TSG101 antibody [4A10] (GTX70255) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255

GTX70255 WB Image

Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with TSG101 antibody [4A10] (GTX70255) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

REFERENCE

Application Reference

Mancarella C et al. Cancer Gene Ther 2023; 30 (9) : 1285-1295 Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells.
Gargiulo E et al. Blood Cancer Discov 2023; 4 (1) : 54-77 Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses.
Zauner R et al. Cancers (Basel) 2023; 15 (13) Biomarker Discovery in Rare Malignancies: Development of a miRNA Signature for RDEB-cSCC.
Zhang C et al. Elife 2023; 12 Syncytin-mediated open-ended membrane tubular connections facilitate the intercellular transfer of cargos including Cas9 protein.
Application : WB
Reactivity : Human
Yuan Y et al. Signal Transduct Target Ther 2023; 8 (1) : 121 Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure.
Application : WB
Reactivity : Mouse
Show More +
Submit a Reference

REVIEW

TSG101 antibody [4A10] Cat. No. GTX70255

Rating
( Average 5 based on 27 users reviews)
Application
Western Blot(WB)
( Average 5 based on 24 users reviews)
Immunocytochemistry/ Immunofluorescence(ICC/IF)
( Average 5 based on 2 users reviews)
IHC (Free Floating)(IHC (Free Floating))
( Average 5 based on 1 users reviews)
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 24-Jul-2023
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the 2021 in Sci Rep. PMID: 34127763
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 24-Jul-2023
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the 2020 in Eur J Neurosci. PMID: 32939863
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 24-Jul-2023
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the 2020 in Eur J Neurosci. PMID: 32939863
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 22-Feb-2022
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the Nat Commun in 2016. PMID: 27882925
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 22-Feb-2022
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the Nat Commun in 2016. PMID: 27882925
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal J Cell Sci in 2015.PMID: 26002056
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal PLoS Biol in 2013.PMID: 23874151
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal J Extracell Vesicles in 2012.PMID: 24009879
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Mol Neurodegener in 2017.PMID: 28835279
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Acta Neuropathol Commun in 2017.PMID: 28851452
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Acta Neuropathol Commun in 2017.PMID: 28851452
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Sci Rep in 2017.PMID: 28303002
Anti-TSG101 antibody [4A10] used in IHC (Free Floating) (IHC (Free Floating)). GTX70255
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : IHC (Free Floating)
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Mol Neurodegener in 2017.PMID: 28835279
Anti-TSG101 antibody [4A10] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX70255
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : ICC/IF
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Mol Neurodegener in 2017.PMID: 28835279
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Acta Neuropathol Commun in 2017.PMID: 28851452
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Nat Commun in 2015.PMID: 26103923
Anti-TSG101 antibody [4A10] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX70255
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : ICC/IF
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS Pathog in 2015. PMID: 25710462
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2017. PMID: 28241021
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Front Neurosci in 2019. PMID: 32009885
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2018. PMID: 29953492
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Cell Death Dis in 2018. PMID: 29743530
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Sci Rep in 2017. PMID: 28963552
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS Pathog in 2016. PMID: 27203423
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Mk
Figure Note : The data was peer reviewed and published in the journal Virol J in 2008. PMID: 18267010
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Int J Mol Sci in 2020. PMID: 32230970
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal J Exp Clin Cancer Res in 2018. PMID: 30290833
Anti-TSG101 antibody [4A10] used in Western Blot (WB). GTX70255
Date : Anonymous submitted on 25-Nov-2019
Score :
Application Tested : WB
Sample Species : Hu, Rat
Sample : HEK293, NRK-52E cells
Amount used : 12.5 μg
Blocking : 0.25 % PVP-40 in TBST, 25°C, 1Hr
Primary Antibody : 1:2000, 4°C, 18Hr
Show More +
Submit a Review
Application Reference
Mancarella C et al. Cancer Gene Ther 2023; 30 (9):1285-1295 Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells.
Gargiulo E et al. Blood Cancer Discov 2023; 4 (1):54-77 Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses.
Zauner R et al. Cancers (Basel) 2023; 15 (13) Biomarker Discovery in Rare Malignancies: Development of a miRNA Signature for RDEB-cSCC.
Mansouri-Kivaj N et al. Stem Cell Res Ther 2023; 14 (1):61 Homogenous subpopulation of human mesenchymal stem cells and their extracellular vesicles restore function of endometrium in an experimental rat model of Asherman syndrome.
Application : WB
Reactivity : Human
Zhang C et al. Elife 2023; 12 Syncytin-mediated open-ended membrane tubular connections facilitate the intercellular transfer of cargos including Cas9 protein.
Application : WB
Reactivity : Human
Yuan Y et al. Signal Transduct Target Ther 2023; 8 (1):121 Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure.
Application : WB
Reactivity : Mouse
Hsueh YH et al. J Orthop Translat 2023; 38:141-155 Therapeutic effect of induced pluripotent stem cell -derived extracellular vesicles in an in vitro and in vivo osteoarthritis model.
Deng W et al. Cell Cycle 2022; 21 (16):1775-1783 In vitro experimental study on the formation of microRNA-34a loaded exosomes and their inhibitory effect in oral squamous cell carcinoma.
Martins-Marques T et al. EMBO Rep 2022; 23 (7):e54312 Cx43-mediated sorting of miRNAs into extracellular vesicles.
Lanna A et al. Nat Cell Biol 2022; 24 (10):1461-1474 An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory.
Application : ELISA
Reactivity : Human
McCann J et al. J Extracell Vesicles 2022; 11 (10):e12220 Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA.
Application : WB
Reactivity : Human
Wu B et al. Carcinogenesis 2022; 43 (11):1059-1070 LAMTOR1 degrades MHC-II via the endocytic in hepatocellular carcinoma.
Application : WB
Reactivity : Human
Valentina Biagini et al. Int J Mol Sci 2022; 23 (10) Zebrafish Melanoma-Derived Interstitial EVs Are Carriers of ncRNAs That Induce Inflammation.
Application : WB
Reactivity : Zebrafish
Michael Schneider et al. Front Oncol 2022; 12:842418 The Chaperone Protein GRP78 Promotes Survival and Migration of Head and Neck Cancer After Direct Radiation Exposure and Extracellular Vesicle-Transfer.
Application : WB
Reactivity : Human
Jo?o Vasco Ferreira et al. Sci Adv 2022; 8 (12):eabm1140 LAMP2A regulates the loading of proteins into exosomes.
Leary N et al. J Extracell Vesicles 2022; 11 (2):e12197 Melanoma-derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes.
Application : WB
Reactivity : Human
Zhang L et al. J Virol 2022;:jvi0000522 Tumor Susceptibility Gene 101 (TSG101) Contributes to Virion Formation of Porcine Reproductive and Respiratory Syndrome Virus via Interaction with the Nucleocapsid (N) Protein along with the Early Secretory Pathway.
Application : WB
Reactivity : Human
Miserey-Lenkei S et al. Biol Cell 2021; 113 (7):311-328 A comprehensive library of fluorescent constructs of SARS-CoV-2 proteins and their initial characterisation in different cell types.
Federico Gulluni et al. Science 2021; 374 (6573):eabk0410 PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Application : WB
Reactivity : Human
Yuan-Kun Tu et al. Curr Neurovasc Res 2021; 18 (4):395-408 Human Olfactory Ensheathing Cell-derived Extracellular Cesicles: miRNA Profile and Neuroprotective Effect.
Application : WB
Reactivity : Human
Alessandra Aiello et al. Viruses 2021; 14 (1) HIV-1 Nef Protein Affects Cytokine and Extracellular Vesicles Production in the GEN2.2 Plasmacytoid Dendritic Cell Line.
Application : WB
Reactivity : Human
Sun T et al. Kaohsiung J Med Sci 2021; (Epub) Exosomal microRNA-19b targets FBXW7 to promote colorectal cancer stem cell stemness and induce resistance to radiotherapy.
Application : WB
Reactivity : Human
Hu R et al. Cell Death Discov 2021; 7 (1):262 LncRNA RP11-465B22.8 triggers esophageal cancer progression by targeting miR-765/KLK4 axis.
Reactivity : Human
Volz AK et al. Nat Commun 2021; 12 (1):5671 Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles.
Application : WB
Reactivity : Human
Cone AS et al. Theranostics 2021; 11 (17):8129-8142 Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model.
Application : WB
Reactivity : Human
Song L et al. J Cell Biol 2021; 220 (9) Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1.
Application : WB
Reactivity : Human
Sun L et al. Sci Rep 2021; 11 (1):12477 Multiplex protein profiling method for extracellular vesicle protein detection.
Application : WB
Reactivity : Human
Haghighitalab A et al. Sci Rep 2021; 11 (1):7825 Investigating the effects of IDO1, PTGS2, and TGF-β1 overexpression on immunomodulatory properties of hTERT-MSCs and their extracellular vesicles.
Application : WB
Reactivity : Human
Shen CH et al. Front Cell Dev Biol 2021; 9:642625 ZNRF1 Mediates Epidermal Growth Factor Receptor Ubiquitination to Control Receptor Lysosomal Trafficking and Degradation.
Application : WB
Reactivity : Human
Hendricks MR et al. Cell Rep 2021; 34 (4):108672 Extracellular vesicles promote transkingdom nutrient transfer during viral-bacterial co-infection.
Application : WB
Inukai R et al. Int J Mol Sci 2021; 22 (3) The Novel ALG-2 Target Protein CDIP1 Promotes Cell Death by Interacting with ESCRT-I and VAPA/B.
Application : WB
Reactivity : Human
Chhoy P et al. STAR Protoc 2021; 2 (1):100303 Protocol for the separation of extracellular vesicles by ultracentrifugation from in vitro cell culture models.
Application : WB
Reactivity : Human
Logozzi M et al. J Enzyme Inhib Med Chem 2021; 36 (1):175-182 Nanovesicles released by OKT3 hybridoma express fully active antibodies.
Application : WB
Reactivity : Mouse
Liu CC et al. J Virol 2021; 95 (6) The ESCRT-I Subunit Tsg101 Plays Novel Dual Roles in Entry and Replication of Classical Swine Fever Virus.
Application : WB
Reactivity : Pig
Xinhui Liu et al. Front Pharmacol 2020; 11:622658 Involvement of Circulating Exosomal MicroRNAs in Jian-Pi-Yi-Shen Formula Protection Against Adenine-Induced Chronic Kidney Disease.
Application : WB
Reactivity : Rat
Martins-Marques T et al. Life Sci Alliance 2020; 3 (12) Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes.
Chen SD et al. Cells 2020; 9 (8) Circulating MicroRNAs from Serum Exosomes May Serve as a Putative Biomarker in the Diagnosis and Treatment of Patients with Focal Cortical Dysplasia.
Haupt M et al. Stem Cells Transl Med 2020; (Epub) Lithium modulates miR-1906 levels of mesenchymal stem cell-derived extracellular vesicles contributing to poststroke neuroprotection by toll-like receptor 4 regulation.
Application : WB
Reactivity : Mouse
Joshi BS et al. Eur J Neurosci 2020; (Epub) Heparan sulfate proteoglycan-mediated dynamin-dependent transport of neural stem cell exosomes in an in vitro blood-brain barrier model.
Application : WB
Reactivity : Human
Turner DL et al. Elife 2020; 9 The host exosome pathway underpins biogenesis of the human cytomegalovirus virion.
Application : WB
Hasegawa K et al. FEBS J 2020; (Epub) Extracellular vesicles derived from inflamed murine colorectal tissue induce fibroblast proliferation via epidermal growth factor receptor.
Application : WB
Reactivity : Mouse
Mukherjee C et al. Cell Metab 2020; 32 (2):259-272.e10 Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain.
Application : WB
Sato M et al. Biochem Biophys Res Commun 2020; 528 (1):199-205 Glucocorticoids negatively regulates chaperone mediated autophagy and microautophagy.
Application : WB
Reactivity : Human
Ou D et al. Cancer Biol Med 2020; 17 (2):328-342 CDK11 negatively regulates Wnt/β-catenin signaling in the endosomal compartment by affecting microtubule stability.
Application : WB
Reactivity : Human
Zheng X et al. Transl Stroke Res 2020; Extracellular Vesicles Derived from Neural Progenitor Cells--a Preclinical Evaluation for Stroke Treatment in Mice.
Application : WB
Reactivity : Mouse
Cone A.S. et al. BMC Molecular and Cell Biology 2020; (Epub) Alix and Syntenin-1 direct amyloid precursor protein and amyloid beta trafficking into extracellular vesicles.
Application : WB
Moertl S et al. Int J Mol Sci 2020; 21 (7) Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.
Application : WB
Reactivity : Human
Firoozi S et al. Biochem Biophys Res Commun 2020; 524 (4):903-909 Mesenchymal stem cell-derived extracellular vesicles alone or in conjunction with a SDKP-conjugated self-assembling peptide improve a rat model of myocardial infarction.
Application : WB
Reactivity : Human
Tanaka K et al. Biochem Biophys Res Commun 2020; (Epub) Ubiquitination of Src promotes its secretion via small extracellular vesicles.
Application : WB
Reactivity : Dog
Willis CM et al. Neurochem Res 2020; (Epub) The Effects of IL-1β on Astrocytes are Conveyed by Extracellular Vesicles and Influenced by Age.
Application : EM
Reactivity : Mouse
Peng KY et al. Brain 2019; 142 (1):163-175 Apolipoprotein E4 genotype compromises brain exosome production.
Batool A et al. Front Neurosci 2019; 13:1404 Altered Biogenesis and MicroRNA Content of Hippocampal Exosomes Following Experimental Status Epilepticus.
Application : WB
Reactivity : Mouse
Abed M et al. PLoS One 2019; 14 (4):e0214110 The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification.
Quinney KB et al. Proc Natl Acad Sci U S A 2019; 116 (14):6858-6867 Growth factor stimulation promotes multivesicular endosome biogenesis by prolonging recruitment of the late-acting ESCRT machinery.
Temoche-Diaz MM et al. Elife 2019; 8 Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes.
Application : WB
Reactivity : Human
Ajasin DO et al. Elife 2019; 8 CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release.
Logozzi M et al. Cancers (Basel) 2019; 11 (10) Increased Plasmatic Levels of PSA-Expressing Exosomes Distinguish Prostate Cancer Patients from Benign Prostatic Hyperplasia: A Prospective Study.
Application : WB
Reactivity : Human
Jain G et al. Transl Psychiatry 2019; 9 (1):250 A combined miRNA-piRNA signature to detect Alzheimer's disease.
Application : WB
Reactivity : Mouse
Pace KR et al. Int J Mol Sci 2019; 20 (16) Exosomal L1CAM Stimulates Glioblastoma Cell Motility, Proliferation, and Invasiveness.
Application : WB
Reactivity : Human
P?rez-Gonz?lez R et al. Sci Rep 2019; 9 (1):11104 Neuroprotection mediated by cystatin C-loaded extracellular vesicles.
Application : WB
Reactivity : Mouse
Schott MB et al. J Cell Biol 2019; Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes.
Reactivity : Rat
Subedi P et al. Anal Biochem 2019; 584:113390 Comparison of methods to isolate proteins from extracellular vesicles for mass spectrometry-based proteomic analyses.
Application : WB
Reactivity : Human
Tsunemi T et al. J Neurosci 2019; (Epub) Increased lysosomal exocytosis induced by lysosomal Ca2+ channel agonists protects human dopaminergic neurons from 帢-synuclein toxicity.
Application : WB
Reactivity : Human
Inoue J et al. J Virol 2019; (Epub) siRNA Screening for the Small GTPase Rab Proteins Identifies that Rab5B is a Major Regulator of Hepatitis B Virus Production.
Application : WB
Reactivity : Human
Brahmer A et al. J Extracell Vesicles 2019; 8 (1):1615820 Platelets, endothelial cells and leukocytes contribute to the exercise-triggered release of extracellular vesicles into the circulation.
Application : WB
Reactivity : Human
View ORCID ProfileMorayma M. Temoche-Diaz et al. bioRxiv 2019; (Epub) Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes.
Application : WB
Reactivity : Human
Streetley J et al. Blood 2019; (Epub) Stimulated release of intraluminal vesicles from Weibel-Palade bodies.
Reactivity : Human
Logozzi M et al. Eur J Pharm Biopharm 2019; 137:23-36 Human primary macrophages scavenge AuNPs and eliminate it through exosomes. A natural shuttling for nanomaterials.
Application : WB
Reactivity : Human
Logozzi M et al. J Enzyme Inhib Med Chem 2019; 34 (1):272-278 Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity.
Application : WB
Reactivity : Human
Wierz M et al. Methods Mol Biol 2019; 1884:231-245 Purification of Leukemia-Derived Exosomes to Study Microenvironment Modulation.
Application : WB
Reactivity : Human
Noh SH et al. Autophagy 2018; 14 (10):1761-1778 Specific autophagy and ESCRT components participate in the unconventional secretion of CFTR.
Javier Pacheco-Quinto et al. FASEB 2018; (Epub) Intracellular metalloprotease activity controls intraneuronal Aβ aggregation and limits secretion of Aβ via exosomes.
Application : WB
Reactivity : Mouse
Novo D et al. Nat Commun 2018; 9 (1):5069 Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels.
Application : WB
Reactivity : Human
Li W et al. J Cell Biochem 2018; (Epub) Detection of exosomal tyrosine receptor kinase B as a potential biomarker in ovarian cancer.
Application : WB
Reactivity : Human
Boussadia Z et al. J Exp Clin Cancer Res 2018; 37 (1):245 Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules.
Application : WB
Reactivity : Human
Winer H et al. Nat Commun 2018; 9 (1):3744 Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins.
Application : WB
Reactivity : Human
Heisler FF et al. Neuron 2018; 99 (6):1155-1169.e9 Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression.
Application : WB
Reactivity : Mouse
Vincent Hyenne et al. bioRxiv 2018; (Epub) Studying the fate of tumor extracellular vesicles at high spatio-temporal resolution using the zebrafish embryo.
Application : WB
Moriwaki Y et al. PLoS One 2018; 13 (6):e0199829 SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes.
Application : WB
Reactivity : Mouse
Gao K et al. Cell Death Dis 2018; 9 (5):528 iASPP-PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation.
Application : ICC/IF
Reactivity : Human
Gartner K et al. Cancer Med 2018; (Epub) Tumor-derived extracellular vesicles activate primary monocytes.
Application : WB
Reactivity : Human
Mutschelknaus L et al. Sci Rep 2017; 7 (1):12423 Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells.
Durcin M et al. J Extracell Vesicles 2017; 6 (1):1305677 Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles.
Lerner N et al. PLoS One 2017; 12 (2):e0171153 Extracellular vesicles mediate signaling between the aqueous humor producing and draining cells in the ocular system.
Jovi?i? A et al. PLoS One 2017; 12 (2):e0171418 Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes.
Guo H et al. Dev Cell 2017; 43 (6):716-730.e7 Atg5 Disassociates the V1V0-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy.
Application : WB
Reactivity : Human
Strickland M et al. Nat Commun 2017; 8 (1):1391 Tsg101 chaperone function revealed by HIV-1 assembly inhibitors.
Application : ICC/IF
Reactivity : Human
Koster S et al. Proc Natl Acad Sci U S A 2017; (Epub) Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA.
Application : WB
Reactivity : Mouse
Gauthier SA et al. Acta Neuropathol Commun 2017; 5 (1):65 Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities.
Application : WB
Reactivity : Human
Willen K et al. Mol Neurodegener 2017; 12 (1):61 Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A.
Application : WB, ICC/IF
Reactivity : Mouse
Wills C.M. et al. Front. Neurosci. 2017; (Epub) A Refined Bead-Free Method to Identify Astrocytic Exosomes in Primary Glial Cultures and Blood Plasma.
Application : WB, EM
Reactivity : Mouse
Durcin M et al. JEV 2017; (Epub) Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles.
Application : WB
Reactivity : Mouse
Sun KT et al. Sci Rep 2017; 7 (1):202 Reciprocal regulation of γ-globin expression by exo-miRNAs: Relevance to γ-globin silencing in β-thalassemia major.
Application : WB
Reactivity : Human
Yentrapalli R et al. Int J Radiat Biol 2017;:43112 Quantitative changes in the protein and miRNA cargo of plasma exosome-like vesicles after exposure to ionizing radiation.
Sung BH et al. Cell Adh Migr 2017;:43109 Exosome secretion promotes chemotaxis of cancer cells.
Application : WB
Reactivity : Human
Villarroya-Beltri C et al. Nat Commun 2016; 7:13588 ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins.
Shurtleff MJ et al. Elife 2016; 5 Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction.
Application : WB
Reactivity : Human
Edgar JR et al. Elife 2016; 5 Tetherin is an exosomal tether.
Application : WB
Reactivity : Human
Castelli G et al. Blood Cells Mol Dis 2016; 61:58-65 Conditioned medium from human umbilical vein endothelial cells markedly improves the proliferation and differentiation of circulating endothelial progenitors.
Application : WB
Reactivity : Human
Kamelgarn M et al. Biochim Biophys Acta 2016; 1862 (10):2004-14 Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS.
Sinha S et al. J Cell Biol 2016; 214 (2):197-213 Cortactin promotes exosome secretion by controlling branched actin dynamics.
Application : WB
Reactivity : Human
Cao H et al. J Biol Chem 2016; (Epub) The Endocytic Fate of the Transferrin Receptor is Regulated by c-Abl Kinase.
Application : WB
Reactivity : Human
Park A et al. PLoS Pathog 2016; 12 (5):e1005659 Nipah Virus C Protein Recruits Tsg101 to Promote the Efficient Release of Virus in an ESCRT-Dependent Pathway.
Application : WB
Reactivity : Human
Kunadt M et al. Acta Neuropathol 2015; 129 (5):695-713 Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation.
Application : WB
Reactivity : Mouse
Yim YI et al. J Cell Sci 2015; 128 (7):1434-43 The multivesicular body is the major internal site of prion conversion.
Application : WB
Reactivity : Mouse
Edgar JR et al. J Cell Sci 2015; 128 (14):226665 ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation.
Application : WB
Reactivity : Mouse
Fabbri A et al. Toxins (Basel) 2015; 7 (11):4610-21 Cell-to-cell propagation of the bacterial toxin CNF1 via extracellular vesicles: potential impact on the therapeutic use of the toxin.
Application : WB
Reactivity : Human
Zhang M et al. Elife 2015; 4 Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion.
Application : WB
Reactivity : Human
Jang ER et al. J Cell Sci 2015; 128 (23):4428-41 Spatial control of Shoc2-scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5.
Application : ICC/IF
Reactivity : Human
Kapustin AN et al. Circ Res 2015; 116 (8):1312-23 Vascular smooth muscle cell calcification is mediated by regulated exosome secretion.
Application : WB
Reactivity : Human
Hyenne V et al. J Cell Biol 2015; 211 (1):27-37 RAL-1 controls multivesicular body biogenesis and exosome secretion.
Prescher J et al. PLoS Pathog 2015; 11 (2):e1004677 Super-resolution imaging of ESCRT-proteins at HIV-1 assembly sites.
Tomas A et al. Nat Commun 2015; 6 (Epub):7324 WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway.
Application : ICC/IF
Reactivity : Human
Fruhbeis C et al. J Extracell Vesicles 2015; 4 (Epub):28239 Physical exercise induces * of small extracellular vesicles into the circulation.
Application : WB
Reactivity : Human
Cicero AL et al. Nat Commun 2015; 6 (Epub):7506 Exosomes released by keratinocytes modulate melanocyte pigmentation.
Application : WB
Reactivity : Human
Kirsten Ridder et al. OncoImmunology 2015; Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment
Application : WB
Reactivity : Mouse
Kojima K et al. J Biol Chem 2014; 289 (48):33296-310 ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.
Reactivity : Human
Traikov S et al. PLoS One 2014; 9 (11):e109372 Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis.
Application : ICC/IF
Reactivity : Human
Calistri A et al. J Cell Physiol 2014; Functional interaction between the ESCRT-I component TSG101 and the HSV-1 tegument ubiquitin specific protease.
Application : IP
Reactivity : Human
Tsunemi T et al. J Neurosci 2014; 34 (46):15281-7 ATP13A2/PARK9 Regulates Secretion of Exosomes and α-Synuclein.
Application : WB
Reactivity : Human
McDonald MK et al. Pain 2014; Functional significance of macrophage-derived exosomes in inflammation and pain.
Application : WB
Reactivity : Mouse
Kolb AR et al. Mol Biol Cell 2014; 25 (2):276-89 ESCRT regulates surface expression of the Kir2.1 potassium channel.
Application : WB
Reactivity : Human
Armstrong A et al. Neuromolecular Med 2014; 16 (1):150-60 Lysosomal Network Proteins as Potential Novel CSF Biomarkers for Alzheimer's Disease.
Application : WB
Reactivity : Human
Rush JS et al. Mol Cell Endocrinol 2013; 381 (43102):188-97 RAB7 and TSG101 are required for the constitutive recycling of unliganded EGFRs via distinct mechanisms.
Application : WB
Reactivity : Human
Fruhbeis C et al. PLoS Biol 2013; 11 (7):e1001604 Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication.
Chudak C et al. Retrovirology 2013; 10:140 Identification of late assembly domains of the human endogenous retrovirus-K(HML-2).
Application : WB
Reactivity : Human
New SE et al. Circ Res 2013; 113 (1):26481 Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques.
Application : WB
Reactivity : Mouse
Colombo M et al. J Cell Sci 2013; 126 (Pt 24):5553-65 Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles.
Application : WB
Reactivity : Human
Pietiainen V et al. J Cell Sci 2013; 126 (Pt 17):3961-71 NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation.
Application : WB
Reactivity : Human
Sorrentino V et al. J Lipid Res 2013; 54 (8):2174-84 The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.
Application : WB
Reactivity : Human
Caduco M et al. J Virol 2013; 87 (1):692-6 Tsg101 interacts with herpes simplex virus 1 VP1/2 and is a substrate of VP1/2 ubiquitin-specific protease domain activity.
Application : WB
Reactivity : Human
Bobrie A et al. J Extracell Vesicles 2012; 1 Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation.
Falguieres T et al. Traffic 2012; 13 (1):131-42 Regulation of the MVB pathway by SCAMP3.
Lee CP et al. PLoS Pathog 2012; 8 (9):e1002904 The ESCRT machinery is recruited by the viral BFRF1 protein to the nucleus-associated membrane for the maturation of Epstein-Barr Virus.
Application : ICC/IF
Reactivity : Human
Choy RW et al. Proc Natl Acad Sci U S A 2012; 109 (30):E2077-82 Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi network.
Brankatschk B et al. Sci Signal 2012; 5 (215):ra21 Regulation of the EGF transcriptional response by endocytic sorting.
Application : WB
Reactivity : Human
Nabhan JF et al. Proc Natl Acad Sci U S A 2012; 109 (11):4146-51 Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein.
Application : WB
Reactivity : Human
Rush JS et al. J Biol Chem 2012; 287 (1):712-22 Endosomal accumulation of the activated epidermal growth factor receptor (EGFR) induces apoptosis.
Tampellini D et al. J Neurosci 2011; 31 (43):15384-90 Impaired β-amyloid secretion in Alzheimer's disease pathogenesis.
Application : ICC/IF
Reactivity : Mouse
Pasqual G et al. PLoS Pathog 2011; 7 (9):e1002232 Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport.
Application : WB
Reactivity : Human
Eyster CA et al. Mol Biol Cell 2011; 22 (17):3218-30 MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation.
Application : WB
Reactivity : Human
Hahn S et al. J Immunol 2011; 186 (10):5706-18 The PTAP sequence within the p6 domain of human immunodeficiency virus type 1 Gag regulates its ubiquitination and MHC class I antigen presentation.
Application : WB
Reactivity : Human
Apaja PM et al. J Cell Biol 2010; 191 (3):553-70 Quality control for unfolded proteins at the plasma membrane.
Application : WB
Reactivity : Human
Dynek JN et al. EMBO J 2010; 29 (24):4198-209 c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.
Application : WB
Reactivity : Human
Balut CM et al. Am J Physiol Cell Physiol 2010; 299 (5):C1015-27 ESCRT-dependent targeting of plasma membrane localized KCa3.1 to the lysosomes.
Application : ICC/IF
Reactivity : Human
Inuzuka T et al. BMC Struct Biol 2010; 10:25 Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition.
Application : WB
Reactivity : Human
Moorman NJ et al. Mol Cell Proteomics 2010; 9 (5):851-60 A targeted spatial-temporal proteomics approach implicates multiple cellular trafficking pathways in human cytomegalovirus virion maturation.
Application : ICC/IF
Reactivity : Human
Leithe E et al. J Cell Sci 2009; 122 (Pt 21):3883-93 Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101.
Application : ICC/IF
Reactivity : Rat
Glozman R et al. J Cell Biol 2009; 184 (6):847-62 N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic.
Application : WB
Reactivity : Human
Chen J et al. Traffic 2009; 10 (10):1488-501 Transferrin-directed internalization and cycling of transferrin receptor 2.
Application : WB
Reactivity : Human
Truschel ST et al. Traffic 2009; 10 (9):1318-36 ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane.
Application : WB
Reactivity : Human
Okumura M et al. Biochem Biophys Res Commun 2009; 386 (1):237-41 Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101.
Application : WB
Aoh QL et al. Mol Biol Cell 2009; 20 (6):1816-32 SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling.
Application : WB
Reactivity : Human
Luyet PP et al. Traffic 2008; 9 (12):2279-90 The ESCRT-I subunit TSG101 controls endosome-to-cytosol release of viral RNA.
Application : WB
Reactivity : Human
Falguieres T et al. Mol Biol Cell 2008; 19 (11):4942-55 In vitro budding of intralumenal vesicles into late endosomes is regulated by Alix and Tsg101.
Application : WB
Reactivity : Hamster
Pons V et al. PLoS Biol 2008; 6 (9):e214 Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies.
Application : WB
Reactivity : Human
Valiathan RR et al. Virol J 2008; 5:23 Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag.
Application : WB
Reactivity : Monkey
Shibata H et al. J Biol Chem 2008; 283 (15):9623-32 Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants.
Application : WB
Reactivity : Human
Ichioka F et al. FEBS J 2008; 275 (4):682-92 Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4).
Application : WB
Reactivity : Human
Filimonenko M et al. J Cell Biol 2007; 179 (3):485-500 Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.
Application : WB
Reactivity : Human
Audhya A et al. PLoS One 2007; 2 (9):e956 MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation.
Application : WB, ICC/IF
Reactivity : Human
Fraile-Ramos A et al. Cell Microbiol 2007; 9 (12):2955-67 The ESCRT machinery is not required for human cytomegalovirus envelopment.
Application : WB
Kramer-Albers EM et al. Proteomics Clin Appl 2007; 1 (11):1446-61 Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
De Domenico I et al. Mol Biol Cell 2007; 18 (7):2569-78 The molecular mechanism of hepcidin-mediated ferroportin down-regulation.
Application : WB
Reactivity : Human
Tampellini D et al. J Biol Chem 2007; 282 (26):18895-906 Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations.
Application : ICC/IF
Reactivity : Mouse
Langelier C et al. J Virol 2006; 80 (19):9465-80 Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release.
Application : ICC/IF
Reactivity : Human
Chertova E et al. J Virol 2006; 80 (18):9039-52 Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages.
Application : WB
Reactivity : Human
Raiborg C et al. J Cell Sci 2006; 119 (Pt 12):2414-24 Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains.
Application : ICC/IF
Reactivity : Human
Razi M et al. Mol Biol Cell 2006; 17 (8):3469-83 Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation.
Application : WB
Reactivity : Human
Almeida CG et al. J Neurosci 2006; 26 (16):4277-88 Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.
Application : ICC/IF
Reactivity : Mouse
Duncan LM et al. EMBO J 2006; 25 (8):1635-45 Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules.
Bache KG et al. Mol Biol Cell 2006; 17 (6):2513-23 The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.
Hui EK et al. J Virol 2006; 80 (5):2291-308 YRKL sequence of influenza virus * functions as the L domain motif and interacts with VPS28 and Cdc42.
Application : WB
Reactivity : Human
Gullapalli A et al. Mol Biol Cell 2006; 17 (3):1228-38 An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins.
Application : WB
Reactivity : Human
Ward DM et al. J Biol Chem 2005; 280 (11):10548-55 The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells.
Application : WB
Reactivity : Human
Lin Y et al. J Biol Chem 2005; 280 (13):12799-809 Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1.
Application : WB
Reactivity : Human
Irie T et al. J Virol 2005; 79 (20):12617-22 L-domain flanking sequences are important for host interactions and efficient budding of vesicular stomatitis virus recombinants.
Application : WB
Katoh K et al. Biochem J 2005; 391 (Pt 3):677-85 The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B.
Cabezas A et al. J Cell Sci 2005; 118 (Pt 12):2625-35 Alix regulates cortical actin and the spatial distribution of endosomes.
Application : WB
Reactivity : Human
Irie T et al. Virology 2005; 336 (2):291-8 Functional characterization of Ebola virus L-domains using VSV recombinants.
Application : WB
Bache KG et al. Mol Biol Cell 2004; 15 (9):4337-46 The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation.
Application : WB
Reactivity : Human
Stuchell MD et al. J Biol Chem 2004; 279 (34):36059-71 The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding.
Application : WB
Reactivity : Human
Sharma M et al. J Cell Biol 2004; 164 (6):923-33 Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes.
Application : WB
Zhu G et al. Int J Cancer 2004; 109 (4):541-7 Reduction of TSG101 protein has a negative impact on tumor cell growth.
Application : WB
Reactivity : Human
Irie T et al. J Virol 2004; 78 (6):2657-65 Budding of PPxY-containing rhabdoviruses is not dependent on host proteins TGS101 and VPS4A.
Application : IP
Reactivity : Human
Heissmeyer V et al. Nat Immunol 2004; 5 (3):255-65 Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins.
Application : WB
Reactivity : Mouse
von Schwedler UK et al. Cell 2003; 114 (6):701-13 The protein network of HIV budding.
Application : WB
Strack B et al. Cell 2003; 114 (6):689-99 AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.
Application : WB
Reactivity : Human
Chiou CT et al. J Gen Virol 2003; 84 (Pt 10):2795-805 Association of Japanese encephalitis virus NS3 protein with microtubules and tumour susceptibility gene 101 (TSG101) protein.
Application : ICC/IF
Reactivity : Hamster
Gottwein E et al. J Virol 2003; 77 (17):9474-85 The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release.
Application : WB
Reactivity : Human
Bache KG et al. J Cell Biol 2003; 162 (3):435-42 Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes.
Application : ICC/IF
Reactivity : Human
Pornillos O et al. J Cell Biol 2003; 162 (3):425-34 HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein.
Application : WB
Reactivity : Human
Zhu G et al. Oncogene 2003; 22 (24):672991 Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer.
Application : IHC
Reactivity : Human
Myers EL et al. J Virol 2002; 76 (22):11226-35 Tsg101, an inactive homologue of ubiquitin ligase e2, interacts specifically with human immunodeficiency virus type 2 gag polyprotein and results in increased levels of ubiquitinated gag.
Application : WB
Reactivity : Human
Bishop N et al. J Cell Biol 2002; 157 (1):91-101 Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates.
Application : WB
Reactivity : Human
Garrus JE et al. Cell 2001; 107 (1):55-65 Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding.
Application : WB
Reactivity : Human
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