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TSH receptor antibody [4C1]

Anti-TSH receptor antibody [4C1] used in IHC (Paraffin sections) (IHC-P). GTX47974

Cat. No. GTX47974

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4C1

Isotype

 IgG2a

Application

 WB, IHC-P, IHC-Fr, FACS, IP

Reactivity

 Human
Package
100 μg ($399)
See all TSH receptor products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1/1,000
IHC-P 1/1,000-1/2,000
IHC-Fr Assay dependent
FACS 1/100-1/1,000
IP Assay dependent

Note :

FACS
Use 10μl of the suggested working dilution to label 106 cells in 100μl.
Not tested in other applications.

Calculated MW

87 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

External domain of human TSH receptor.

Purification

Protein A purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_510211

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

thyroid stimulating hormone receptor , CHNG1 , LGR3 , hTSHR-I

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Database

Research Area

DATA IMAGES

Anti-TSH receptor antibody [4C1] used in IHC (Paraffin sections) (IHC-P). GTX47974

GTX47974 IHC-P Image

IHC-P analysis of human thyroid tissue using GTX47974 TSH receptor antibody [4C1].

REFERENCE

Application Reference

Shepherd PS et al. Mol Cell Endocrinol 1999; 149 (43102) : 197-206 Identification of an important thyrotrophin binding site on the human thyrotrophin receptor using monoclonal antibodies.
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399