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TSH receptor antibody [4C1]

Anti-TSH receptor antibody [4C1] used in IHC (Paraffin sections) (IHC-P). GTX47974

Cat. No. GTX47974

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4C1

Isotype

 IgG2a

Application

 WB, IHC-P, IHC-Fr, FACS, IP

Reactivity

 Human
Package
100 μg ($399)
See all TSH receptor products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1/1,000
IHC-P 1/1,000-1/2,000
IHC-Fr Assay dependent
FACS 1/100-1/1,000
IP Assay dependent

Note :

FACS
Use 10μl of the suggested working dilution to label 106 cells in 100μl.
Not tested in other applications.

Calculated MW

87 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

External domain of human TSH receptor.

Purification

Protein A purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_510211

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

thyroid stimulating hormone receptor , CHNG1 , LGR3 , hTSHR-I

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Database

Research Area

DATA IMAGES

Anti-TSH receptor antibody [4C1] used in IHC (Paraffin sections) (IHC-P). GTX47974

GTX47974 IHC-P Image

IHC-P analysis of human thyroid tissue using GTX47974 TSH receptor antibody [4C1].

REFERENCE

Application Reference

N Woodbury et al. Research Square 2023; Predicting Monoclonal Antibody Binding Sequences from a Sparse Sampling of All Possible Sequences
Shepherd PS et al. Mol Cell Endocrinol 1999; 149 (43102) : 197-206 Identification of an important thyrotrophin binding site on the human thyrotrophin receptor using monoclonal antibodies.
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399