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TTBK1 antibody

Anti-TTBK1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85349
Anti-TTBK1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85349
Anti-TTBK1 antibody used in Western Blot (WB). GTX85349

Cat. No. GTX85349

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse
Package
100 μg ($399)
See all TTBK1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

143 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , Jurkat Cell Lysate(GTX27899)

Product Note

Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

TTBK1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human TTBK1.The immunogen is located within amino acids 1190 - 1240 of TTBK1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tau tubulin kinase 1 , BDTK

Cellular Localization

Cytoplasm

Background

Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer’s disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.

Database

Research Area

DATA IMAGES

Anti-TTBK1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85349

GTX85349 IHC-P Image

IHC-P analysis of human brain tissue using GTX85349 TTBK1 antibody.
Working concentration : 20 μg/ml

Anti-TTBK1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85349

GTX85349 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX85349 TTBK1 antibody.
Working concentration : 2.5 μg/ml

Anti-TTBK1 antibody used in Western Blot (WB). GTX85349

GTX85349 WB Image

WB analysis of Jurkat cell lysate using GTX85349 TTBK1 antibody.
Working concentration : 1 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399