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TTK antibody

KO/KD Orthogonal
Anti-TTK antibody used in Western Blot (WB). GTX16407
Anti-TTK antibody used in Immunohistochemistry (IHC). GTX16407
Anti-TTK antibody used in Immunohistochemistry (IHC). GTX16407

Cat. No. GTX16407

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, IHC

Reactivity

 Human
Package
100 μl ($399)
See all TTK products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

97 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 517-856 of human TTK (NP_001160163.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_2887537

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TTK protein kinase , CT96 , ESK , MPH1 , MPS1 , MPS1L1 , PYT

Background

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Database

Research Area

DATA IMAGES

Anti-TTK antibody used in Western Blot (WB). GTX16407

GTX16407 WB Image

WB analysis of HeLa cell lysate using GTX16407 TTK antibody.
Dilution : 1:2000
Loading : 25μg per lane

Anti-TTK antibody used in Immunohistochemistry (IHC). GTX16407

GTX16407 IHC Image

Orthogonal

The data was published in the journal Int J Mol Sci in 2020. PMID: 32121246

Anti-TTK antibody used in Immunohistochemistry (IHC). GTX16407

GTX16407 IHC Image

KO/KD

The data was published in the journal Int J Mol Sci in 2020. PMID: 32121246

REFERENCE

Application Reference

Tsai YM et al. Int J Mol Sci 2020; 21 (5) Upregulation of Thr/ Tyr kinase Increases the Cancer Progression by Neurotensin and Dihydropyrimidinase-Like 3 in Lung Cancer.
Application : IHC-P
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399