Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Dilution |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
*liver left adrenal vein tissue
Predict Reactivity
Human, Bovine, Pig(>80% identity)
Form
Liquid
Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1mg/ml(Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant protein encompassing a sequence within the center region of human TXA synthase. The exact sequence is proprietary.
Purification
Purified by antigen-affinity chromatography.
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Synonyms
CYP5 antibody, CYP5A1 antibody, FLJ52771 antibody, GHOSAL antibody, THAS antibody, TS antibody, TXAS antibody, TXS antibody, TBXAS1 antibody, "platelet, cytochrome P450, subfamily V antibody", TXA synthase antibody, thromboxane-A synthase antibody, "thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) antibody", cytochrome P450 5A1 antibody, "cytochrome P450, family 5, subfamily A, polypeptide 1 antibody", thromboxane A synthase 1 (platelet) antibody
Cellular Localization
Membrane; Multi-pass membrane protein
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Database
Research Area
