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TXNRD2 antibody

Anti-TXNRD2 antibody used in IHC (Paraffin sections) (IHC-P). GTX112199
Anti-TXNRD2 antibody used in Western Blot (WB). GTX112199
Anti-TXNRD2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX112199

Cat. No. GTX112199

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human
Package
100 μl ($399),
25 μl ($169)
See all TXNRD2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

56 kDa. ( Note )

Positive Control

HepG2

Predict Reactivity

Mouse, Rat, Guinea pig, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 20% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human TXNRD2. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_11166826

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

thioredoxin reductase 2 , GCCD5 , SELZ , TR , TR-BETA , TR3 , TRXR2

Cellular Localization

Mitochondrion

Background

Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-TXNRD2 antibody used in IHC (Paraffin sections) (IHC-P). GTX112199

GTX112199 IHC-P Image

Immunohistochemical analysis of paraffin-embedded HBL435 xenograft, using TrxR2(GTX112199) antibody at 1:500 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-TXNRD2 antibody used in Western Blot (WB). GTX112199

GTX112199 WB Image

Sample (30 ug of whole cell lysate)
A: HepG2
7.5% SDS PAGE
GTX112199 diluted at 1:1000

Anti-TXNRD2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX112199

GTX112199 ICC/IF Image

TrxR2 antibody detects TrxR2 protein at mitochondria by immunofluorescent analysis.
Sample: HeLa cells were fixed in 2% paraformaldehyde/culture medium at 37ºC for 30 min.
Green: TrxR2 protein stained by TrxR2 antibody (GTX112199) diluted at 1:500.
Blue: Hoechst 33342 staining.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 399
$ 169