GeneTex
United States (US)

TYK2 antibody

GTX30812_20170605_ICCIF_18121410_402.jpg
GTX30812_20170605_WB_18121410_976.jpg

Cat No. GTX30812

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:2,000
ICC/IF Assay dependent
Not tested in other applications.

Calculated MW

134 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

0.01M PBS pH7.4, 15 mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

synthetic peptide corresponding to amino acids 1046-1060 of human TYK2.

Purification

IgG fraction

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

JTK1

Background

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq]

Database

Research Area

DATA IMAGES
GTX30812_20170605_ICCIF_18121410_402.jpg

GTX30812 ICC/IF Image

ICC/IF analysis of HUVEC cells using GTX30812 TYK2 antibody at 1:100 (red)with Hoescht 33342 (blue).

GTX30812_20170605_WB_18121410_976.jpg

GTX30812 WB Image

WB analysis of HEK-293T cells overexpressing human TYK2 using GTX30812 TYK2 antibody at 1:1000.

Package List Price ($)
$ 319