GeneTex
United States (US)

TYK2 antibody

GTX31515_2706_WB_20180221_18121410_867.jpg

Cat No. GTX31515

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ELISA
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 - 2 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

134 kDa. ( Note )

Positive Control

Human Small Intestine Tissue Lysate(GTX27923)

Specificity/Sensitivity

At least three isoforms of TYK2 are known to exist; this antibody only detects the two longest isoforms.
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Rabbit polyclonal TYK2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TYK2.The immunogen is located within amino acids 90 - 140 of TYK2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Tyrosine Kinase 2,Imd35,Jtk1,Tyk2

Background

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX31515_2706_WB_20180221_18121410_867.jpg

GTX31515 WB Image

WB analysis of human small intestine tissue lysate using GTX31515 TYK2 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

Package List Price ($)
$ 339