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TYK2 antibody

Anti-TYK2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX31515
Anti-TYK2 antibody used in Western Blot (WB). GTX31515

Cat. No. GTX31515

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all TYK2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
ICC/IF Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

134 kDa. ( Note )

Positive Control

Human Small Intestine Tissue Lysate(GTX27923)

Product Note

At least three isoforms of TYK2 are known to exist; this antibody only detects the two longest isoforms.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Rabbit polyclonal TYK2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TYK2.The immunogen is located within amino acids 90 - 140 of TYK2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tyrosine kinase 2 , IMD35 , JTK1

Background

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-TYK2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX31515

GTX31515 ICC/IF Image

ICC/IF analysis of A549 cells using GTX31515 TYK2 antibody.
Dilution : 20 μg/ml

Anti-TYK2 antibody used in Western Blot (WB). GTX31515

GTX31515 WB Image

WB analysis of human small intestine tissue lysate using GTX31515 TYK2 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399