Talin antibody recognizes the cytoskeletal component talin, a ~270 kDa protein involved in cell mechanotransduction that links the cytoskeleton to integrins. It forms an antiparallel homodimer and interacts with vinculin, actin, and integrins. Talin is incorporated very early in the cell-extracellular matrix (ECM) adhesion process.
*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
Rat, Bovine, Chicken(>80% identity)
1XPBS (pH7), 20% Glycerol
0.025% ProClin 300
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.54 mg/ml (Please refer to the vial label for the specific concentration.)
Recombinant protein encompassing a sequence within the center region of human Talin-1. The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
talin 1 , ILWEQ , TLN , talin-1
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]