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Tapasin antibody

Anti-Tapasin antibody used in Western Blot (WB). GTX13518

Cat. No. GTX13518

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IP

Reactivity

 Human, Mouse, Rat, Bovine
Package
50 μg ($399)
See all Tapasin products

APPLICATION

Application Note

IP: Use at a dilution of 1/100. WB: Use at a dilution of 1/1000. Detects a band of approximately 48 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

48 kDa. ( Note )

Positive Control

HeLa Cell Lysate

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: LGWAAVYLSTCKDSKKKAE , corresponding to amino acids 430-448 of Human Tapasin.

Purification

Protein A affinity purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TAP binding protein , NGS17 , TAPA , TPN , TPSN

Cellular Localization

Endoplasmic reticulum membrane

Background

This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Tapasin antibody used in Western Blot (WB). GTX13518

GTX13518 WB Image

Western blot analysis of Tapasin, PAb:
Lane 1: MW marker
Lane 2: A431 Lysate

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399