For IHC-P: Use at an assay dependent dilution. For WB: Use at a concentration of 1-2 μg/ml. Optimal dilutions/concentrations should be determined by the researcher.
GTX12356 stains the human neurofibrillary tangles, neuropil threads and neuritic plaques associated with Alzheimer's disease. The antibody also stains astrocytes and ribosomes. Tau-2 may be used with formalin-fixed paraffin-embedded sections of human brain tissue.
Phosphate-buffered saline, pH 7.4, and 150 mM NaCl containing 0.09% sodium azide and 1% BSA
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.1 mg/ml (Please refer to the vial label for the specific concentration.)
Recombinant full length protein
Protein A/G purified
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
microtubule associated protein tau , DDPAC , FTDP-17 , MAPTL , MSTD , MTBT1 , MTBT2 , PPND , PPP1R103 , TAU
Cytoplasm, cytosol , Cell membrane , Cytoplasm, cytoskeleton , Cytoplasm , Cell projection, dendrite
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]