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Tau (phospho Ser400) antibody

Orthogonal
Anti-Tau (phospho Ser400) antibody used in Western Blot (WB). GTX49377

Cat. No. GTX49377

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ELISA

Reactivity

 Human, Mouse, Rat
Package
40 μg ($399)
See all Tau products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5-2μg/ml
ELISA 0.05-0.2μg/ml
Not tested in other applications.

Calculated MW

79 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 30% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH-conjugated synthetic phospho-peptide mapping to residues surrounding Serine-400 of human Tau-F. A portion of this peptide contains the sequence PVVSGDT common to Tau isoforms (UniProt accession #P10636).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

DDPAC , FTDP17 , MAPT , MAPTL , MSTD , MTBT1 , MTBT2 , PPND , PPP1R103 , TAU , microtubule associated protein tau , Tau , Neurofibrillary tangles , NFTs

Cellular Localization

Cytoplasm,Cytosol,Cell membrane,Cytoskeleton,Cell projection,Axon

Background

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Tau (phospho Ser400) antibody used in Western Blot (WB). GTX49377

GTX49377 WB Image

Orthogonal

WB analysis of mouse brain tissue lysate using GTX49377 Tau (phospho Ser400) antibody.
Lane 1 : Rabbit IgG Control
Lane 2 : Primary antibody
Lane 3 : Primary antibody pre-incubated with non-phospho-peptide
Lane 4 : Primary antibody pre-incubated with phospho-peptide
Lane 5 : Primary antibody pre-incubated with generic phosphoserine containing peptide

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399