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Tau (phospho Tyr18) antibody [9G3]

Anti-Tau (phospho Tyr18) antibody [9G3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX54658
Anti-Tau (phospho Tyr18) antibody [9G3] used in Western Blot (WB). GTX54658

Cat. No. GTX54658

Reference 3

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 9G3

Isotype

 IgG2a

Application

 WB, ICC/IF, IHC

Reactivity

 Human, Mouse, Rat
Package
50 μg ($399)
See all Tau products

APPLICATION

Application Note

IF: 1:2000 - 1:5000. IHC: 1:1000 - 1:5000. WB: 1:1000 - 1:5000

Calculated MW

79 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Phospho-Tau (tyr 18).

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

microtubule associated protein tau , DDPAC , FTDP-17 , MAPTL , MSTD , MTBT1 , MTBT2 , PPND , PPP1R103 , TAU

Cellular Localization

Cytoplasm, cytosol , Cell membrane , Cytoplasm, cytoskeleton , Cytoplasm , Cell projection, dendrite

Background

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Tau (phospho Tyr18) antibody [9G3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX54658

GTX54658 ICC/IF Image

ICC/IF analysis of HeLa cells transfected with (A) Tau and (B) Tau + Fyn uaing Tau (phospho Tyr18) antibody at a dilution of 1:200.

Anti-Tau (phospho Tyr18) antibody [9G3] used in Western Blot (WB). GTX54658

GTX54658 WB Image

WB analysis of lysates from HeLa cells (4) untransfected and transfected with (1) Tau, (2) Tau + Fyn, (3) Tau + Src, (5) TauY18F, (6) TauY18F + Fyn and (7) TauY18F + Src using Tau (phospho Tyr18) antibody [9G3].

REFERENCE

Application Reference

Mart?nez-M?rmol R et al. Mol Psychiatry 2023; 28 (2) : 946-962 Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates.
Application : WB
Reactivity : Human
Aguilar-Pineda JA et al. iScience 2021; 24 (9) : 102993 Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease.
Application : WB
Reactivity : Human
Egervari G et al. Nat Commun 2020; 11 (1) : 4634 Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder.
Application : WB, ICC/IF
Reactivity : Human
Submit a Reference

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Package List Price ($)
$ 399