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TdT antibody [MSVA-453R] HistoMAX™

HistoMAX
Anti-TdT antibody [MSVA-453R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04417
Anti-TdT antibody [MSVA-453R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04417
Anti-TdT antibody [MSVA-453R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04417

Cat. No. GTX04417

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 MSVA-453R

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($629),
100 μl ($299)
See all TdT products
PRODUCT

Summary

This antibody was validated on 76 different Normal Tissues by IHC-P.

Go to Normal Tissue GalleryGo to Cancer Tissue Gallery

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:75-1:150

Note :

IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 7.8 Tris-EDTA-based Target Retrieval Solution buffer.
Not tested in other applications.

Calculated MW

59 kDa. ( Note )

Positive Control

Thymus: At least a moderate nuclear immunostaining should be seen in virtually all cortical lymphocytes of the normal thymus.

Negative Control

Thymus: The vast majority of the medullary lymphocytes of the normal thymus should be negative. ; Tonsil: The vast majority of lymphoid cells and all epithelial cells should be negative.

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA (Please contact us for sodium azide-free or sodium azide and BSA-free format)

Preservative

0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human DNTT protein

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

DNA nucleotidylexotransferase , TDT

Cellular Localization

Nucleus

Background

This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-TdT antibody [MSVA-453R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04417

GTX04417 IHC-P Image

IHC-P analysis of human merkel cell carcinoma tissue section using GTX04417 TdT antibody [MSVA-453R] HistoMAX™.
Merkel cell carcinoma with strong TdT positivity in 5 of tumor cells.

Anti-TdT antibody [MSVA-453R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04417

GTX04417 IHC-P Image

IHC-P analysis of human thymoma tissue section using GTX04417 TdT antibody [MSVA-453R] HistoMAX™.
Strong TdT immunostaining in a thymoma.

Anti-TdT antibody [MSVA-453R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04417

GTX04417 IHC-P Image

IHC-P analysis of human merkel cell carcinoma tissue section using GTX04417 TdT antibody [MSVA-453R] HistoMAX™.
Merkel cell carcinoma with moderate to strong TdT immunostaining in 80 of tumor cells.

REFERENCE

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REVIEW

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Package List Price ($)
$ 629
$ 299