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Terminal Complement Complex antibody [aE11]

Cat. No. GTX54459

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 aE11

Isotype

 IgG2a

Application

 IHC-P, IHC-Fr, FACS, ELISA, Neutralizing/Inhibition

Reactivity

 Human, Pig, Horse
Package
50 μg ($399)
See all Terminal Complement Complex products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
ELISA Assay dependent
Neutralizing/Inhibition Assay dependent

Note :

IHC-Fr
Cryosections of 10 μm were dried, fixed in acetone at 4ºC for 10 min, dried and blocked for 20 min with PBSA.

Neutralizing/Inhibition
Antibody aE11 inhibits platelet activation by antiphospholipid antibody serum.
Not tested in other applications.

Calculated MW

63 kDa. ( Note )

Product Note

Monoclonal antibody aE11 reacts with a C9 neoantigen of the terminal complement complex (TCC) consisting of C5B, C6, C7, C8, C9 (PubMed ID: 4035298). The TCC contains neoantigens that are absent from the individual native components.- C9 neoantigens are present both in the membrane-bound (MAC) and the fluid-phase (SC5b-9) complex.

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS, 0.1% BSA

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

100 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Purification

Protein G purified

Endotoxin

< 24 EU/mg (Determined by LAL assay)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ARMD15,C9,C9D,complement C9,Complement C9

Cellular Localization

Secreted,Target cell membrane

Background

This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 399