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Thyroglobulin antibody [TGB/1970R]

Anti-Thyroglobulin antibody [TGB/1970R] used in IHC (Paraffin sections) (IHC-P). GTX02720

Cat. No. GTX02720

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 TGB/1970R

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
100 μg ($529)
See all Thyroglobulin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1-2 μg/ml

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

305 kDa. ( Note )

Product Note

We do not recommend use of this product for Mouse,Rat samples.

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full-length human Thyroglobulin protein

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

thyroglobulin , AITD3 , TGN

Cellular Localization

Secreted

Background

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]

Database

Research Area

DATA IMAGES

Anti-Thyroglobulin antibody [TGB/1970R] used in IHC (Paraffin sections) (IHC-P). GTX02720

GTX02720 IHC-P Image

IHC-P analysis of human thyroid tissue section using GTX02720 Thyroglobulin antibody [TGB/1970R].

REFERENCE

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REVIEW

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Package List Price ($)
$ 529