APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:1,000 |
| 1:20-1:500 |
| 1:20 |
| Assay dependent |
| Assay dependent |
| Assay dependent |
| Assay dependent |
Not tested in other applications.
Calculated MW
Product Note
This antibody is specific for the TR beta-1 isoform. This antibody recognizes an epitope in the A/B domain of human TR beta-1, amino acid residues 1-101.
PROPERTIES
Form
Liquid
Buffer
PBS pH7.4, 1mg/ml BSA
Preservative
0.05% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Purified human TR beta -1 protein.
Purification
Protein A purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
thyroid hormone receptor beta , C-ERBA-2 , C-ERBA-BETA , ERBA2 , GRTH , NR1A2 , PRTH , THR1 , THRB1 , THRB2
Cellular Localization
Nucleus
Background
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
![Anti-Thyroid Hormone Receptor beta antibody [J52] used in IHC (Paraffin sections) (IHC-P). GTX22744](/templates/default/js/lightbox/images/loading.gif "Anti-Thyroid Hormone Receptor beta antibody [J52] used in IHC (Paraffin sections) (IHC-P). GTX22744")
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GTX22744 IHC-P Image
IHC-P analysis of human colon tissue using GTX22744 Thyroid Hormone Receptor beta antibody [J52].
Right : Primary antibody
Left : Negative control without primary antibody
Antigen retrieval : 10mM sodium citrate (pH 6.0), microwaved for 8-15 min
Dilution : 1:20
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GTX22744 IHC-P Image
IHC-P analysis of human thyroid tissue using GTX22744 Thyroid Hormone Receptor beta antibody [J52].
Left : Primary antibody
Right : Negative control without primary antibody
Antigen retrieval : heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes
Dilution : 1:20
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GTX22744 WB Image
WB analysis of samples using GTX22744 Thyroid Hormone Receptor beta antibody [J52].
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REFERENCE
There are currently no references for Thyroid Hormone Receptor beta antibody [J52] (GTX22744). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Thyroid Hormone Receptor beta antibody [J52] (GTX22744). Be the first to share your experience with this product.
![Anti-Thyroid Hormone Receptor beta antibody [J52] used in IHC (Paraffin sections) (IHC-P). GTX22744](/upload/website/prouct_img/small/GTX22744/GTX22744_1096_IHC-P_w_23060620_762.webp "Anti-Thyroid Hormone Receptor beta antibody [J52] used in IHC (Paraffin sections) (IHC-P). GTX22744")
![Anti-Thyroid Hormone Receptor beta antibody [J52] used in IHC (Paraffin sections) (IHC-P). GTX22744](/upload/website/prouct_img/small/GTX22744/GTX22744_1095_IHC-P_w_23060620_183.webp "Anti-Thyroid Hormone Receptor beta antibody [J52] used in IHC (Paraffin sections) (IHC-P). GTX22744")
![Anti-Thyroid Hormone Receptor beta antibody [J52] used in Western Blot (WB). GTX22744](/upload/website/prouct_img/small/GTX22744/GTX22744_1581_WB_w_23060620_879.webp "Anti-Thyroid Hormone Receptor beta antibody [J52] used in Western Blot (WB). GTX22744")
![Anti-Thyroid Hormone Receptor beta antibody [J52] used in IHC (Paraffin sections) (IHC-P). GTX22744](/upload/website/prouct_img/normal/GTX22744/GTX22744_1096_IHC-P_w_23060620_762.webp "Anti-Thyroid Hormone Receptor beta antibody [J52] used in IHC (Paraffin sections) (IHC-P). GTX22744")
![Anti-Thyroid Hormone Receptor beta antibody [J52] used in IHC (Paraffin sections) (IHC-P). GTX22744](/upload/website/prouct_img/normal/GTX22744/GTX22744_1095_IHC-P_w_23060620_183.webp "Anti-Thyroid Hormone Receptor beta antibody [J52] used in IHC (Paraffin sections) (IHC-P). GTX22744")
![Anti-Thyroid Hormone Receptor beta antibody [J52] used in Western Blot (WB). GTX22744](/upload/website/prouct_img/normal/GTX22744/GTX22744_1581_WB_w_23060620_879.webp "Anti-Thyroid Hormone Receptor beta antibody [J52] used in Western Blot (WB). GTX22744")