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Thyroid Hormone Receptor beta antibody [N1N3]

Orthogonal
Anti-Thyroid Hormone Receptor beta antibody [N1N3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX113278
Anti-Thyroid Hormone Receptor beta antibody [N1N3] used in Western Blot (WB). GTX113278
Anti-Thyroid Hormone Receptor beta antibody [N1N3] used in Western Blot (WB). GTX113278

Cat. No. GTX113278

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF

Reactivity

 Human, Mouse
Package
100 μl ($399),
25 μl ($169)
See all Thyroid Hormone Receptor beta products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
ICC/IF 1:100-1:1000
Not tested in other applications.

Calculated MW

53 kDa. ( Note )

Positive Control

HepG2

Predict Reactivity

Rat, Sheep(>80% identity)

PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.76 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human Thyroid Hormone Receptor beta. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1952239

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

thyroid hormone receptor beta , C-ERBA-2 , C-ERBA-BETA , ERBA2 , GRTH , NR1A2 , PRTH , THR1 , THRB1 , THRB2

Cellular Localization

Nucleus

Background

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-Thyroid Hormone Receptor beta antibody [N1N3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX113278

GTX113278 ICC/IF Image

Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Thyroid Hormone Receptor beta(GTX113278) antibody at 1:200 dilution.

Anti-Thyroid Hormone Receptor beta antibody [N1N3] used in Western Blot (WB). GTX113278

GTX113278 WB Image

Sample (30 ug of whole cell lysate)
A: Hep G2 (GTX27900)
10% SDS PAGE
GTX113278 diluted at 1:1000
Anti-Thyroid Hormone Receptor beta antibody [N1N3] used in Western Blot (WB). GTX113278

GTX113278 WB Image

Orthogonal

The data was published in the journal Front Physiol in 2016.PMID: 27909409

REFERENCE

Application Reference

Moreno M et al. Front Physiol 2016; 7 : 545 3,5,3'-Triiodo-L-Thyronine- and 3,5-Diiodo-L-Thyronine- Affected Metabolic Pathways in Liver of LDL Receptor Deficient Mice.
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REVIEW

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SDS
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 399
$ 169