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Thyroid Hormone Receptor beta antibody [SPM222]

Anti-Thyroid Hormone Receptor beta antibody [SPM222] used in IHC (Paraffin sections) (IHC-P). GTX17898

Cat. No. GTX17898

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 SPM222

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human, Dog
Package
250 μl ($399)
See all Thyroid Hormone Receptor beta products

APPLICATION

Application Note

IHC-P: 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

53 kDa. ( Note )

Positive Control

C32 cells Colon carcinoma

Product Note

Recognises human thyroid receptor beta, does not recognise alpha 1 and alpha 2 isotypes.

PROPERTIES

Form

Liquid

Buffer

10mM PBS pH7.4, BSA

Preservative

Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: GMSEACLHRKSHSERRSTLK, corresponding to N terminal amino acids 31-50 of Human Thyroid Hormone Receptor beta.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

thyroid hormone receptor beta , C-ERBA-2 , C-ERBA-BETA , ERBA2 , GRTH , NR1A2 , PRTH , THR1 , THRB1 , THRB2

Cellular Localization

Nucleus

Background

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Thyroid Hormone Receptor beta antibody [SPM222] used in IHC (Paraffin sections) (IHC-P). GTX17898

GTX17898 IHC-P Image

Immunohistochemistry using GTX17898 on human colon carcinoma at 1/50

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399