IHC-P: 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Optimal dilutions/concentrations should be determined by the end user.
C32 cells Colon carcinoma
Recognises human thyroid receptor beta, does not recognise alpha 1 and alpha 2 isotypes.
10mM PBS pH7.4, BSA
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Synthetic peptide: GMSEACLHRKSHSERRSTLK, corresponding to N terminal amino acids 31-50 of Human Thyroid Hormone Receptor beta.
Protein G purified
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
thyroid hormone receptor beta , C-ERBA-2 , C-ERBA-BETA , ERBA2 , GRTH , NR1A2 , PRTH , THR1 , THRB1 , THRB2
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]